Recent Advance of Melatonin

Dear Colleagues,

Melatonin is a hormone produced by the pineal gland and is a potent-free radical scavenger and antioxidant. It scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), stimulates the activity of antioxidant enzymes, inhibits proinflammatory cytokines, and activates adhesion molecules in various tissues. In the last few decades, there has been notable progress in understanding the molecular and cellular basis of the complex process of biogenesis of melatonin and its derivatives. Melatonin can preserve the levels of glutathione (GSH) in the mitochondria of the the cell, which help to suppress oxidative damage, resulting in cellular senescence. Accumulated scientific evidence supports that melatonin attenuates not only oxidative damage in neural tissues during developmental stages but also in parenchymal tissues of vital organs. In this Special Issue titled “Recent Advances in Melatonin”, we will deal with the underlying molecular–cellular–biochemical involvement of melatonin not only in homeostasis but also in allostasis of human pathophysiology. Here, we would like to gather manuscripts focused on recently updated research on melatonin and its related areas.

Prof. Yonggeun Hong
Guest Editor

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