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8.3
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Journals
Biomolecules
Special Issues
Recent Advance of Melatonin
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Recent Advance of Melatonin

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 25281

Special Issue Editor

Prof. Dr. Yonggeun Hong

E-Mail Website
Guest Editor
Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Biohealth Products Research Center (BPRC), u-Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimahe, Korea
Interests: regulation of biological clock; degenerative neural diseases; regulation of clock-clontrolled genes by melatonin; anti-aging process in neural tissue by melatonin; melatonin effect in ASD during developmental stages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Melatonin is a hormone produced by the pineal gland and is a potent-free radical scavenger and antioxidant. It scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), stimulates the activity of antioxidant enzymes, inhibits proinflammatory cytokines, and activates adhesion molecules in various tissues. In the last few decades, there has been notable progress in understanding the molecular and cellular basis of the complex process of biogenesis of melatonin and its derivatives. Melatonin can preserve the levels of glutathione (GSH) in the mitochondria of the the cell, which help to suppress oxidative damage, resulting in cellular senescence. Accumulated scientific evidence supports that melatonin attenuates not only oxidative damage in neural tissues during developmental stages but also in parenchymal tissues of vital organs. In this Special Issue titled “Recent Advances in Melatonin”, we will deal with the underlying molecular–cellular–biochemical involvement of melatonin not only in homeostasis but also in allostasis of human pathophysiology. Here, we would like to gather manuscripts focused on recently updated research on melatonin and its related areas.

Prof. Yonggeun Hong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • homeostasis and allostasis of melatonin
  • role of melatonin in degenerative diseases
  • mitochondrial relevance of melatonin
  • cognition exaltation by melatonin
  • application of phytomelatonin
  • melatonin biosynthesis

Published Papers (3 papers)

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Review

16 pages, 762 KiB  
Review
Role of Melatonin in the Synchronization of Asexual Forms in the Parasite Plasmodium falciparum
by Maneesh Kumar Singh, Bárbara Karina de Menezes Dias and Célia R. S. Garcia
Biomolecules 2020, 10(9), 1243; https://doi.org/10.3390/biom10091243 - 27 Aug 2020
Cited by 9 | Viewed by 3531
Abstract
The indoleamine compound melatonin has been extensively studied in the regulation of the circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in Protozoan parasites, especially in the synchronization of the human malaria parasite Plasmodium falciparum via a [...] Read more.
The indoleamine compound melatonin has been extensively studied in the regulation of the circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in Protozoan parasites, especially in the synchronization of the human malaria parasite Plasmodium falciparum via a complex downstream signalling pathway. Melatonin activates protein kinase A (PfPKA) and requires the activation of protein kinase 7 (PfPK7), PLC-IP3, and a subset of genes from the ubiquitin-proteasome system. In other parasites, such as Trypanosoma cruzi and Toxoplasma gondii, melatonin increases inflammatory components, thus amplifying the protective response of the host’s immune system and affecting parasite load. The development of melatonin-related indole compounds exhibiting antiparasitic properties clearly suggests this new and effective approach as an alternative treatment. Therefore, it is critical to understand how melatonin confers stimulatory functions in host–parasite biology. Full article
(This article belongs to the Special Issue Recent Advance of Melatonin)
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28 pages, 1828 KiB  
Review
Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease
by Diana Maria Chitimus, Mihaela Roxana Popescu, Suzana Elena Voiculescu, Anca Maria Panaitescu, Bogdan Pavel, Leon Zagrean and Ana-Maria Zagrean
Biomolecules 2020, 10(9), 1211; https://doi.org/10.3390/biom10091211 - 20 Aug 2020
Cited by 147 | Viewed by 12477
Abstract
There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as [...] Read more.
There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies. Full article
(This article belongs to the Special Issue Recent Advance of Melatonin)
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26 pages, 1182 KiB  
Review
Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases
by Dongmei Chen, Tao Zhang and Tae Ho Lee
Biomolecules 2020, 10(8), 1158; https://doi.org/10.3390/biom10081158 - 07 Aug 2020
Cited by 70 | Viewed by 8783
Abstract
Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning in the central or peripheral nervous system. The prevention of neurodegenerative disorders has become an emerging public health challenge for our society. Melatonin, [...] Read more.
Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning in the central or peripheral nervous system. The prevention of neurodegenerative disorders has become an emerging public health challenge for our society. Melatonin, a pineal hormone, has various physiological functions in the brain, including regulating circadian rhythms, clearing free radicals, inhibiting biomolecular oxidation, and suppressing neuroinflammation. Cumulative evidence indicates that melatonin has a wide range of neuroprotective roles by regulating pathophysiological mechanisms and signaling pathways. Moreover, melatonin levels are decreased in patients with neurodegenerative diseases. In this review, we summarize current knowledge on the regulation, molecular mechanisms and biological functions of melatonin in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, vascular dementia and multiple sclerosis. We also discuss the clinical application of melatonin in neurodegenerative disorders. This information will lead to a better understanding of the regulation of melatonin in the brain and provide therapeutic options for the treatment of various neurodegenerative diseases. Full article
(This article belongs to the Special Issue Recent Advance of Melatonin)
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