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Biomolecules
Special Issues
Biomolecular Signatures in Reactive Stroma—Inflammation and Wound Healing
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Biomolecular Signatures in Reactive Stroma—Inflammation and Wound Healing

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 2501

Special Issue Editor

Dr. Frederick H. Silver

E-Mail Website
Guest Editor
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA
Interests: collagen self-assembly; collagen structure and properties; extracellular matrix, tissue biomechanics; mechanotransduction; non-invasive characterization of tissues; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Synthesis, deposition, and remodeling of the stroma are complex biological processes that are critical to the development and maintenance of tissue homeostasis and repair of injured tissues. As a result of both autoimmune diseases such as Scleroderma and severe burn injuries, tissue fibrosis results in impaired function. In healing wounds, it can lead to hypertrophic scarring that requires surgical correction. Inflammation is a key player in wound healing and involves growth factors, cytokines, matrix metalloproteinases, cellular receptors, and components of the extracellular matrix (ECM). Chronic inflammation, if not resolved, leads to atherosclerosis, leukocyte migration into lesions, and endothelial cell ECM remodeling. This can lead to aortic aneurysm rupture, stromal weakening, and fibrosis. Inflammatory macrophages can differentiate into myofibroblasts limiting tissue regeneration and promoting fibrosis. Tissue fibrosis and the role of ECM components in diabetes, graft-versus-host disease, and hypertrophic scarring as a result of burn injuries all involve inflammation. The relationship between inflammation and wound healing of the stroma is a topic that is important to understanding health and the onset of diseases.

The purpose of this Special Issue is to provide insight into how inflammation and wound healing affect the tissue stroma in health and disease.

Dr. Frederick Silver
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • collagen
  • fibrosis
  • inflammation
  • wound healing
  • impaired function

Published Papers (1 paper)

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Research

16 pages, 2524 KiB  
Article
Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?
by Frederick H. Silver, Nikita Kelkar, Tanmay Deshmukh, Kelly Ritter, Nicole Ryan and Hari Nadiminti
Biomolecules 2021, 11(11), 1712; https://doi.org/10.3390/biom11111712 - 17 Nov 2021
Cited by 7 | Viewed by 2069
Abstract
Early detection of skin cancer is of critical importance since the five-year survival rate for early detected skin malignancies is 99% but drops to 27% for cancer that has spread to distant lymph nodes and other organs. Over 2.5 million benign skin biopsies [...] Read more.
Early detection of skin cancer is of critical importance since the five-year survival rate for early detected skin malignancies is 99% but drops to 27% for cancer that has spread to distant lymph nodes and other organs. Over 2.5 million benign skin biopsies (55% of the total) are performed each year in the US at an alarming cost of USD ~2.5 B. Therefore there is an unmet need for novel non-invasive diagnostic approaches to better differentiate between cancerous and non-cancerous lesions, especially in cases when there is a legitimate doubt that a biopsy may be required. The purpose of this study is to determine whether the differences in the extracellular matrices among normal skin, actinic keratosis (AK), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) can be assessed non-invasively using vibrational optical coherence tomography (VOCT). VOCT is a new diagnostic technology that uses infrared light and audible sound applied transversely to tissue to measure the resonant frequencies and elastic moduli of cells, dermal collagen, blood vessels and fibrous tissue in skin and lesion stroma without physically touching the skin. Our results indicate that the cellular, vascular and fibrotic resonant frequency peaks are altered in AK, BCC and SCC compared to those peaks observed in normal skin and can serve as physical biomarkers defining the differences between benign and cancerous skin lesions. The resonant frequency is increased from a value of 50 Hz in normal skin to a value of about 80 Hz in pre- and cancerous lesions. A new vascular peak is seen at 130 Hz in cancerous lesions that may reflect the formation of new tumor blood vessels. The peak at 260 Hz is similar to that seen in the skin of a subject with Scleroderma and skin wounds that have healed. The peak at 260 Hz appears to be associated with the deposition of large amounts of stiff fibrous collagen in the stroma surrounding cancerous lesions. Based on the results of this pilot study, VOCT can be used to non-invasively identify physical biomarkers that can help differentiate between benign and cancerous skin lesions. The appearance of new stiff cellular, fragile new vessels, and stiff fibrous material based on resonant frequency peaks and changes in the extracellular matrix can be used as a fingerprint of pre- and cancerous skin lesions. Full article
(This article belongs to the Special Issue Biomolecular Signatures in Reactive Stroma—Inflammation and Wound Healing)
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