Up-to-Date of Parathyroid Hormone-Related Protein as a Multifunctional Cytokine in Renal Physiology and Pathophysiology
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (13 August 2021) | Viewed by 3898
Special Issue Editors
Interests: bisphenol A; parathyroid hormone related protein (PTHrP) experimental nephrology; diabetic nephropathy; acute kidney injury (AKI)
Special Issues, Collections and Topics in MDPI journals
Interests: osteoblast; osteoporosis; bone remodeling; bone regeneration; PTHrP; renal tubular; kidney damage
Special Issue Information
Dear Colleagues,
Parathyroid hormone (PTH)-related protein (PTHrP) was initially isolated from hypercalcemia-associated tumors. PTHrP later emerged as a pleiotropic growth factor/cytokine, participating in a variety of homeostatic networks: a regulator of vasodilatation, inflammation, cell proliferation, and differentiation in the vast majority of normal tissues. PTHrP and its characterized PTH/PTHrP type 1 receptor are widely expressed in the kidney, where PTHrP exerts a modulatory role on renal function. Furthermore, PTHrP is known to be upregulated in several experimental nephropathies, such as acute kidney injury (AKI), obstructive nephropathy (ON), as well as both experimental and human diabetic nephropathy (DN). The aim of this Special Issue of Biomolecules is to provide an updated view of PTHrP as an important renal cytokine and its impact on renal physiology and pathophysiology. For this purpose, contributions were selected based on the expertise of recognized scientists in the field. Discussions in this volume include the described features of PTHrP as a survival factor for glomerular mesangial and tubular cells, as well as a modulator of kidney vasculature and glomerular filtration. In addition, data are reported on PTHrP displaying proinflammatory and profibrogenic actions, including the induction of epithelial–mesenchymal transition, in the acutely damaged kidney. PTHrP participation in the mechanisms of renal hypertrophy as well as proteinuria in DN is also discussed.
Moreover, the content of this journal issue deals with the interaction between angiotensin II (Ang II), a critical factor in renal injury, and PTHrP in the injured kidney, providing novel insights into the renal protection conferred by Ang II antagonists, and paving the way for new therapeutic approaches. Recent data showing that PTHrP is excreted in the urine and correlated with renal function are critically discussed; specifically, the possibility that PTHrP could represent a novel urinary biomarker. In summary, we hope the different topics regarding PTHrP in the renal system presented in this volume will be found to be attractive for both basic and clinical researchers in the field.
Prof. Ricardo José Bosch
Dr. Pedro Esbrit
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Parathyroid hormone (PTH)-related protein (PTHrP)
- Acute kidney injury (AKI)
- Obstructive nephropathy (ON)
- Inflammation
- Diabetic nephropathy
- Renal biomarker
- Fibrosis, apoptosis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
