H₂S, Polysulfides, and Enzymes: Physiological and Pathological Aspects: 2nd Edition

Dear Colleagues,

This Special Issue was organized with the intent of elucidating novel physiological and pathological functions of H₂S and polysulfides and explaining the regulation of the pathways and enzymes involved in their biosynthesis. We expect this Issue to advance scientific knowledge regarding the exact functions of H₂S and polysulfides and the general properties and regulation of the enzymes involved in their metabolism, including cystathionine β-synthase (EC 4.2.1.22, CBS), cystathionine γ-lyase (EC 4.4.1.1, CTH), thiosulfate sulfurtransferase (EC 2.8.1.1, rhodanese, TST), and 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2, MST). Five topics will be covered: the biosynthesis of H₂S and polysulfides; biosynthetic enzymes, as well as their properties and regulation; H₂S-releasing pharmaceuticals; the physiological role of H₂S and polysulfides in, e.g., synaptic transmission, vascular tone, inflammation, angiogenesis; and their role in several pathological processes, e.g., healing of ulcers, neurological disorders, myocardial infarction, ischemia–reperfusion injury, heart failure, carcinogenesis, pulmonary, renal, and hepatic diseases, and diabetes. We encourage scientists studying H₂S and polysulfides (mechanisms of biosynthesis, functions, and clinical usage) and related enzymes (structure, reaction mechanisms, and regulation of enzymatic activity) to contribute to this Special Issue. Research articles, clinical studies, and reviews are welcome. For authors interested in submitting a paper, please refer to the Biomolecules “Author Guidelines”.

Dr. Maria Wróbel
Dr. Halina Jurkowska
Guest Editors

Manuscript Submission Information

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