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Special Issue "Cell-Free Approaches and Therapeutic Biomolecules for Cardiac Regeneration"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 15 February 2020.
Cardiac regenerative medicine is regarded as one of the key technologies of the present and near future, with potential novel therapeutic opportunities for cardiovascular diseases. Revolutionary breakthroughs have been made in the last two decades, including the generation of induced pluripotent stem cells (iPS), gaining insight into fundamental regenerative mechanisms by -omics, and the development of cell-free therapuetics. Beyond using stem and progenitor cells, regenerative medicine includes the application of cell-free materials such as secretomes, cell-derived extracellular vesicles (EVs), growth factors, noncoding RNAs and gene therapies, biomaterials, and engineered tissues. In principle, regenerative medicine can be invoked by two complementary strategies: (1) stimulation of an endogenous repair mechanism by applied therapeutics (synthetic or biologically derived factors, genetic and epigenetic modifications) and (2) exogenous regeneration through use of cells, tissues or other biotechnological products (advanced therapy medicinal products, ATMPs). Despite great biological and preclinical advancements, translation to therapeutic application of regenerative cells in humans has failed so far. Although based on strongly convincing preclinical data, most of the large clinical trials with cell-based therapies in cardiovascular regenerative medicine have failed to achieve a meaningful and clinically significant benefit. According to the technical difficulties in obtainment, selection, purification, and storage of autologous stem and progenitor cells, the focus of research transposed to off-the-shelf products to use allogenous cell products and small molecules for cardiac repair.
In this Special Issue of Biomolecules called “Cell-Free Approaches and Therapeutic Biomolecules for Cardiac Regeneration“, we invite research papers and reviews reporting cardiac regeneration achieved or failing to be achieved using small molecules, noncoding RNAs, exosomes or any other cell-free substances, or stimulating the endogenous repair mechanisms, or revealing basic mechanistic insight into cardiac reapir mechanisms, with emphasis on the translational importance of research.
Prof. Dr. Mariann Gyöngyösi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cardiac repair
- cell-free therapies in cardiac regeneration
- translational model of human diseases
- ischemic and non-ischemic heart diseases
- noncoding RNAs
- regenerative biomaterials