Cell-Free Approaches and Therapeutic Biomolecules for Cardiac Regeneration
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 38290
Special Issue Editor
Interests: long COVID-19; post-COVID-19; multiorgan disease; cardiac regeneration; cell-based and cell-free therapies; translational animal models of cardiac diseases; ischemic heart diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiac regenerative medicine is regarded as one of the key technologies of the present and near future, with potential novel therapeutic opportunities for cardiovascular diseases. Revolutionary breakthroughs have been made in the last two decades, including the generation of induced pluripotent stem cells (iPS), gaining insight into fundamental regenerative mechanisms by -omics, and the development of cell-free therapuetics. Beyond using stem and progenitor cells, regenerative medicine includes the application of cell-free materials such as secretomes, cell-derived extracellular vesicles (EVs), growth factors, noncoding RNAs and gene therapies, biomaterials, and engineered tissues. In principle, regenerative medicine can be invoked by two complementary strategies: (1) stimulation of an endogenous repair mechanism by applied therapeutics (synthetic or biologically derived factors, genetic and epigenetic modifications) and (2) exogenous regeneration through use of cells, tissues or other biotechnological products (advanced therapy medicinal products, ATMPs). Despite great biological and preclinical advancements, translation to therapeutic application of regenerative cells in humans has failed so far. Although based on strongly convincing preclinical data, most of the large clinical trials with cell-based therapies in cardiovascular regenerative medicine have failed to achieve a meaningful and clinically significant benefit. According to the technical difficulties in obtainment, selection, purification, and storage of autologous stem and progenitor cells, the focus of research transposed to off-the-shelf products to use allogenous cell products and small molecules for cardiac repair.
In this Special Issue of Biomolecules called “Cell-Free Approaches and Therapeutic Biomolecules for Cardiac Regeneration“, we invite research papers and reviews reporting cardiac regeneration achieved or failing to be achieved using small molecules, noncoding RNAs, exosomes or any other cell-free substances, or stimulating the endogenous repair mechanisms, or revealing basic mechanistic insight into cardiac reapir mechanisms, with emphasis on the translational importance of research.
Prof. Dr. Mariann Gyöngyösi
Guest Editor
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Keywords
- cardiac repair
- cell-free therapies in cardiac regeneration
- translational model of human diseases
- ischemic and non-ischemic heart diseases
- exosomes
- noncoding RNAs
- regenerative biomaterials
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