The Role of Glia in Alzheimer's Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 10159
Special Issue Editor
Special Issue Information
Dear Colleagues,
Alzheimer's disease (AD) is a devastating neurodegenerative disease and the leading cause of dementia worldwide. AD is characterized by the presence of abnormal protein deposits, inflammation in the brain, vascular changes, necroptosis activation, and associated neuronal loss. Recent advances in genome-wide association studies and single-cell transcriptomic studies from post-mortem brain samples and experimental animal models strongly implicate glial cells in the pathogenesis of AD. Our understanding of glia biology in the disease onset and progression of AD is swiftly evolving.
Therefore, this Biomolecules Special Issue centers around the latest developments concerning the involvement and contributions of glial cells in AD. The subjects covered will encompass, but will not be restricted to, the involvement of glia, including microglia, astrocytes, oligodendrocytes, and Ng2 cells, in AD's pathogenesis and their therapeutic implications. This Special Issue showcases the role of glial cells, their context-dependent neuroprotective and neurotoxic functions, multi-faced cellular states, and their response during the disease. We welcome original contributions and review articles that provide comprehensive overviews of the latest literature. Gaining insights into both the cellular autonomous and non-cell autonomous functions of the glia holds great potential for developing targeted therapies to modulate glial behavior to promote neuroprotection and alleviate the disease.
Dr. Sriram Balusu
Guest Editor
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Keywords
- Alzheimer's disease
- neurodegeneration
- glial cells
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