Role of Thiols in Oxidant-Induced Injuries

Dear Colleagues,

This Special Issue will focus on the role of thiols in oxidant-induced injuries. Reactive oxygen species (ROS), such as hydrogen peroxide and hydroxyl radicals, are reactive molecules that are produced during cellular metabolism, inflammatory responses, metabolism of drugs and toxicants and from exposure to environmental stressors. Excessive production of ROS can damage to cells, proteins, lipids, and DNA, resulting in turn in various diseases and conditions such as cancer, diabetes, cardiovascular conditions, neurodegenerative diseases, and aging. Among the several antioxidants that scavenge or neutralize ROS, thiols play an important role in protecting cells against oxidant-induced injuries. Thiols contain sulfhydryl groups, which are highly nucleophilic and readily donate electrons to free radicals and other oxidizing agents. Thiols can act as antioxidants, regulate cellular signaling pathways, and recycle other antioxidants. The depletion of thiols is known to increase susceptibility of cells and tissues to oxidant-induced injury.

This Special Issue will cover a range of topics that relate to thiol involvement in oxidative stress and its effects on cellular function and disease. Such topics may include: the involvement of thiols in cellular antioxidant defence, thiol-based therapy, redox homeostasis, measurement of thiol levels in biological samples, mechanism of thiol oxidation and repair, thiol modification of proteins and its effects on function, thiol’s involvement in the development and progression of oxidant-induced injuries, and the effects of dietary thiols in oxidative stress.

Prof. Dr. Zacharias Suntres
Guest Editor

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• cysteine
• sulfhydryl
• thiol
• antioxidants
• reactive oxygen species
• free radicals
• oxidant-induced injuries