Role of Glutathione Peroxidase in Health and Disease

Dear Colleagues,

Selenium (Se)-dependent glutathione peroxidases (GPX) and now, Se-independent GPXs, have been linked to disease (Kashan) and numerous pathologies, cancer foremost (10% of publications). The Guest Editor, in reviewing GPX2 work, found technical flaws, errors in interpretation, and, often, results that defied understanding in much of the work. This Special Issue is soliciting work on GPXs and health (stock animals, poultry, and humans) that truly advances the field and meets higher standards of workmanship than most papers currently accepted for publication. Reviews pointing out the items mentioned above will not be considered. Ferroptosis papers must feature GPX4 as the focus or be rejected. To promote reproducibility, the editor encourages the use of Se supplementation in cell culture. In cell line work using mRNA silencing or overexpression, the impact on protein levels must be shown in a single Western blot with all the parental lines included or with reference high- and low-expressing lines; likewise, for RT-PCR. In work involving GPX2, the GPX1 expression must be included as part of the data. In work using 2’,7’-dichlorodihydrofluorescein diacetate, testing resistance to oxidants or impact on cell properties, a second comparable antioxidant enzyme should be silenced or overexpressed to support the results (GPX1, where GPX2 is studied; PRDX1, or 2, where GPX1 is studied, etc.). Kaplan–Meier (K–M) curves should have cut-offs that make sense relative to significant expression levels, not always median levels. Cell lines used to validate K–M analysis should have comparable TPM (tumors extrapolated to 100% purity). IHC-based K–M analyses should show intensity and proportion separately.

Dr. R Steve Esworthy
Guest Editor

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• GPX1
• GPX2
• GPX3
• GPX4
• GPX5
• GPX6
• GPX7
• GPX8
• selenium
• cancer
• pathology