From Dietary Polyphenols to Senolytic Supplements in the Search of the “Fountain of Youth”—Honorary Special Issue Commemorating the Pioneering Work of Prof. Giulio Maria Pasinetti

Dear Colleagues,

Dr. Pasinetti is the Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS). He is also the Director of the Basic and Biomedical Research and Training Program at GRECC of the James J. Peters Veterans Affairs Medical Center, Bronx, NY.

He is currently the Director of the Center for Molecular Neuroresilience at the Icahn School of Medicine at Mount Sinai, funded by the Office of Dietary Supplements (ODS) and National Center for Complementary and Integrative Health (NCCIH) as part of the Center for Advancing Research on Botanical and Other Natural Products (CARBON).

Over the past two decades, Dr. Pasinetti developed interest in the metabolism of dietary polyphenols and their impact on the gut microbiome and the different mechanisms through which the gut microbiome may promote cognitive resilience against stress-induced disorders. His research into the metabolic functions of bacterial populations in the gut microbiome has allowed for the identification of novel bioactive and brain-bioavailable compounds that are capable of therapeutically engaging mechanisms associated with not only psychiatric disorders, but also neurodegeneration. Most importantly, Dr. Pasinetti focused on mechanistic-based approaches to validate sensible and reliable translational tools to detect and assess relevant signatures of brain-bioavailable polyphenol compound bioactivities in experimental models attenuate synaptic maladaptation by utilizing nutrition-based approaches to promote resilience that can eventually translate to the clinical setting. In the last few years, Dr. Pasinetti focus has expanded to further understand the role of the innate immune system and the role of the inflammasome and its contribution to Alzheimer’s disease and psychiatric disorders. 

In honor of Dr. Pasinetti’s pioneering work, this Special Issue is intended as a forum to compile current research related to the utilization of polyphenolic nutritional supplements to modulate the immune system and improve neuroresilience. By doing so, the Special Issue aims to highlight the latest in experimental designs and techniques to provide the current foundation for the next generation of researchers to develop the next line of innovative and rigorous studies.

Prof. Dr. Gemma Casadesus Smith
Guest Editor

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• Alzheimer’s disease
• supplements
• amyloid-β
• tau
• microglia
• immunomodulator