New Insights into Computational Genomics

Dear Colleagues,

The past few years have seen the emergence of novel experimental strategies that have revolutionised our capability to study the genome, epigenome, and transcriptome of living organisms. The advent of long-read sequencing, which can identify complex structural variants to study the epigenome and the transcriptome with unprecedented resolution, and the diffusion of single-cell sequencing in biomedical research settings paved the way for the detection and quantitative analysis of cellular content, allowing the profiling of the omic layers of single cells and laying the groundwork for heterogeneity-oriented studies. As experimental protocols have improved rapidly, computational workflows for processing the data have also been refined, enabling novel methods capable of handling this continuously growing data. This Special Issue invites articles that address the many aspects of the analyses of single-cell and long-read sequencing data, highlighting the key technological and computational developments that favoured their adoption in clinical applications.

Dr. Alberto Magi
Dr. Roberto Semeraro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• single-cell omics
• long reads
• algorithms
• computational methods
• genomics
• transcriptomics
• epigenomics