New Insight into Subphases of DNA Replication in Mammalian Cells
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 185
Special Issue Editor
Interests: origin and structure of nucleic acids; chromosome condensation; metastatic spread of abdominal tumors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Around sixty years ago, it was not known whether replicative DNA synthesis of the leading strand of the DNA duplex in mammalian (particularly in human) cells is a continuous process or is interrupted, and if it is, how many times in the S phase. The generally accepted view of discontinuous synthesis of the lagging strand forming Okazaki fragments should not be confused with that of the leading strand synthesis. Over the past 40 years, it turned out that it has still not been clarified how many subphases of the leading strand synthesis of replication are.
In this Special Issue, we welcome scientists who have contributed to the field with their commendable publication(s) worth to discuss how many (if any) subphases are in the replication, and authors are asked to describe the method(s) that allowed them to come to their conclusions.
Keywords: exponentially growing cells; cell cycles; subdivisions of the S phase; replicative and repair synthesis; active replication regions; replication peaks; subphases of replication; chromosome folding; DNA content; chromosomal aberrations.
Methods of interest: flow cytometry; bromdeoxyuridine labeling; BrdU–Giemsa technique; electron-microscopic autography; X-ray irradiation; and counterflow centrifugal elutriation.
Prof. Dr. Gaspar Banfalvi
Guest Editor
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Keywords
- DNA content
- chromosomal aberrations
- replication peaks
- subphases of replication
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