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Biomimetics
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Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition
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Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Development of Biomimetic Methodology".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 5366

Special Issue Editors

Prof. Dr. Vicente Javier Clemente-Suárez

E-Mail Website
Guest Editor
Faculty of Sports Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain
Interests: child stress; physiology; psychology; nutrition; health; disease; environment
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ana Isabel Beltrán-Velasco

E-Mail Website
Guest Editor
NBC Group, School of Life and Nature Sciences, Nebrija University, 28240 Madrid, Spain
Interests: behavioral psychology; psychological testing; psychological assessment; public health; neurodegenerative disease; psychological health; pathological mechanisms and therapeutic opportunities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, ‘Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition’, explores the innovative intersection of healthcare and nature-inspired solutions. This Special Issue will delve into the emerging field of biomimetics, where scientists and healthcare professionals draw inspiration from the natural world to develop groundbreaking healthcare technologies and strategies. By mimicking biological processes, structures, and systems found in the environment, researchers aim to create effective and sustainable solutions for healthcare challenges. This Special Issue will feature contributions that showcase how biomimetic approaches are revolutionizing medical diagnostics, treatment modalities, and healthcare practices. From bio-inspired materials for regenerative medicine to nature-inspired algorithms for healthcare data analysis, this Special Issue will highlight the diverse applications of biomimetics in improving healthcare outcomes.

Prof. Dr. Vicente Javier Clemente-Suárez
Prof. Dr. Ana Isabel Beltrán-Velasco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetics
  • healthcare innovations
  • nature-inspired solutions
  • medical diagnostics
  • regenerative medicine
  • bio-inspired materials
  • healthcare data analysis
  • natural algorithms
  • biologically inspired technology
  • sustainable healthcare

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Related Special Issues

Published Papers (4 papers)

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Research

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13 pages, 3541 KB  
Article
The Impact of Collagen Fiber and Slit Orientations on Meshing Ratios in Skin Meshing Models
by Masoumeh Razaghi Pey Ghaleh and Denis O’Mahoney
Biomimetics 2025, 10(11), 771; https://doi.org/10.3390/biomimetics10110771 - 14 Nov 2025
Viewed by 512
Abstract
Skin meshing facilitates the greater expansion of donor skin through patterned slits and is widely used for treating extensive burn injuries. However, the actual expansion often falls below manufacturers’ claims. Previous computational analyses using the isotropic Yeoh model have shown that Langer’s line [...] Read more.
Skin meshing facilitates the greater expansion of donor skin through patterned slits and is widely used for treating extensive burn injuries. However, the actual expansion often falls below manufacturers’ claims. Previous computational analyses using the isotropic Yeoh model have shown that Langer’s line orientation and slit direction significantly affect induced stress and meshing ratios, yet the use of nonlinear anisotropic models that represent collagen fiber alignment corresponding to Langer’s lines remains unexplored. This study employs a nonlinear anisotropic Gasser–Ogden–Holzapfel (GOH) model with slit orientations of 0°, 45°, and 90°, consistent with geometries reported in the literature, to quantify induced stress in skin meshing by incorporating collagen fibers within the dermis layer. The GOH parameters were calibrated to human back skin data uniaxially stretched parallel and perpendicular to Langer’s lines using Levenberg–Marquardt optimization in the GIBBON toolbox (MATLAB R2023a) coupled with FEBio v4.0, achieving a standard deviation of 3% relative to experimental data. The GOH model predicted the highest induced stress at 100% strain for the 45° slit parallel to Langer’s lines and the lowest for the 90° slit perpendicular, exceeding 40 MPa due to absence of damage and rupture modeling but accurately representing anisotropic mesh behavior. Full article
(This article belongs to the Special Issue Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition)
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24 pages, 6188 KB  
Article
A Bionic Sensing Platform for Cell Separation: Simulation of a Dielectrophoretic Microfluidic Device That Leverages Dielectric Fingerprints
by Reza Hadjiaghaie Vafaie, Elnaz Poorreza, Sobhan Sheykhivand and Sebelan Danishvar
Biomimetics 2025, 10(11), 753; https://doi.org/10.3390/biomimetics10110753 - 7 Nov 2025
Viewed by 567
Abstract
Cancers are diseases described by the irregular spread of cells that have developed invasive features, enabling them to invade adjacent tissues. The specific diagnosis and effective management of oncological treatments depend on the timely detection of circulating tumor cells (CTCs) in a patient’s [...] Read more.
Cancers are diseases described by the irregular spread of cells that have developed invasive features, enabling them to invade adjacent tissues. The specific diagnosis and effective management of oncological treatments depend on the timely detection of circulating tumor cells (CTCs) in a patient’s bloodstream. One of the most promising approaches to CTC separation from blood fractions involves the dielectrophoresis (DEP) technique. This research presents a new DEP-based bionic system designed for MDA-MB-231 breast cancer cell isolation from white blood cell (WBC) subtypes with a viable approach to cell viability. This work leverages the principle that every cell type possesses a unique dielectric fingerprint. This dielectrophoresis microfluidic device is designed to act as a scanner, reading these fingerprints to achieve a continuous, label-free separation of cancer cells from blood components with a high efficiency. In the proposed system that consists of three different stages, the first stage allows for separating B-lymphocytes and Monocytes from Granulocytes and MDA-MB-231 cells. The separation of B-lymphocytes from Monocytes occurs in the second step, while the last step concerns the separation of Granulocytes and MDA-MB-231 cells. In the analysis, x-y graphs of the electric potentials, velocity fields, pressure distributions, and cellular DEP forces applied to the cells, as well as the resulting particle paths, are provided. The model predicts that the system operates with a separation efficiency of nearly 92%. This work focuses on an investigation of the impact of electrode potentials, the velocity of cells, the number of electrodes, the width of the channel, and the output angles on enhancing the separation efficiency of particles. Full article
(This article belongs to the Special Issue Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition)
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15 pages, 858 KB  
Article
Efficacy and Safety of Kahook Dual Blade Goniotomy and Trabecular Micro-Bypass Stent in Combination with Cataract Extraction
by Kevin Y. Wu, Shu Yu Qian, Lysa Houadj and Michael Marchand
Biomimetics 2025, 10(10), 691; https://doi.org/10.3390/biomimetics10100691 - 14 Oct 2025
Viewed by 932
Abstract
In recent years, rapid advancements in glaucoma research have led to the development of more effective treatments of this chronic and irreversible condition. Of these, Kahook Blade Dual (KDB) goniotomy and second-generation trabecular micro-bypass stent (iStent) are two novel biomimetic procedures which have [...] Read more.
In recent years, rapid advancements in glaucoma research have led to the development of more effective treatments of this chronic and irreversible condition. Of these, Kahook Blade Dual (KDB) goniotomy and second-generation trabecular micro-bypass stent (iStent) are two novel biomimetic procedures which have designs inspired by the eye’s natural drainage mechanisms. In this retrospective study, we evaluated the safety and effectiveness of both surgeries by including 176 eyes from 110 patients: 142 eyes in the iStent group and 34 in the KDB group. The primary outcomes of this study were the proportions of patients in each group attaining a 20% reduction in IOP and a post-operative IOP < 19 mmHg. At the last follow-up, a 20% reduction in IOP was achieved by 67% of iStent inject patients and 50% of KDB patients (p = 0.07). The iStent group also showed a higher proportion of patients reaching an IOP of less than 19 mmHg (81% vs. 71% in the KDB group, p = 0.13). The number of medications did not decrease in either group from pre-op to the last follow-up. The KDB group had more failures (29.4% vs. 4.2%) and a significantly higher adverse event rate than the iStent inject group (47.1% vs 12.0%). Full article
(This article belongs to the Special Issue Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition)
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Review

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43 pages, 1468 KB  
Review
Biometric Strategies to Improve Vaccine Immunogenicity and Effectiveness
by Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Alvaro Bustamante-Sánchez, Alexandra Martín-Rodríguez, Rodrigo Yáñez-Sepúlveda and Jose Francisco Tornero-Aguilera
Biomimetics 2025, 10(7), 439; https://doi.org/10.3390/biomimetics10070439 - 3 Jul 2025
Cited by 2 | Viewed by 3113
Abstract
Background: Vaccines have revolutionized disease prevention, yet their effectiveness is challenged by variable immunogenicity, individual response differences, and emerging variants. Biomimetic strategies, inspired by natural immune processes, offer new avenues to enhance vaccine performance. Objectives: This narrative review examines how bioinspired approaches—grounded in [...] Read more.
Background: Vaccines have revolutionized disease prevention, yet their effectiveness is challenged by variable immunogenicity, individual response differences, and emerging variants. Biomimetic strategies, inspired by natural immune processes, offer new avenues to enhance vaccine performance. Objectives: This narrative review examines how bioinspired approaches—grounded in evolutionary medicine, immunology, and host–microbiota interactions—can improve vaccine immunogenicity and long-term protection. We further examine the evolutionary foundations of immune responses, highlighting how an evolutionary perspective can inform the development of durable, broadly protective, and personalized vaccines. Furthermore, mechanistic insights at the molecular and cellular level are explored, including Toll-like receptor (TLR) engagement, dendritic cell activation pathways, and MHC-I/MHC-II-mediated antigen presentation. These mechanisms are often mimicked in biomimetic systems to enhance uptake, processing, and adaptive immune activation. Results: The review highlights how immunosenescence, maternal immunity, genetic variation, and gut microbiota composition influence vaccine responses. Biomimetic platforms—such as nanoparticle carriers and novel adjuvants—enhance antigen presentation, boost adaptive immunity, and may overcome limitations in traditional vaccine approaches. Additionally, co-administration strategies, delivery systems, and microbiota-derived immunomodulators show promise in improving vaccine responsiveness. Conclusions: Integrating biomimetic and evolutionary principles into vaccine design represents a promising path toward safer, longer-lasting, and more effective immunizations Full article
(This article belongs to the Special Issue Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 3rd Edition)
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