Advances in Pharmacology of Pain and Inflammation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 19
Special Issue Editors
Interests: pharmacology of pain; chronic pain
Interests: chronic inflammatory diseases and inflammatory conditions of the respiratory tract
Special Issue Information
Dear Colleagues,
Globally, 7 of the 10 leading causes of death in recent years were non-communicable diseases, accounting for approximately 38% of all deaths or 68% of the 10 leading causes. These include several painful (oncological pain and neuropathies) and inflammatory (diseases and cancers of the respiratory tract) conditions. The treatment of neuropathic pain is challenging due to its heterogeneous etiologies, lack of objective diagnostic tools, and resistance to classic analgesic drugs. Recommended first-line treatments include gabapentinoids, tricyclic antidepressants and selective serotonin, and norepinephrine reuptake inhibitors.
The inflammatory response involves cellular effectors and chemicals that participate in a wide variety of diseases, such as Chronic Obstructive Pulmonary Disease (COPD). This disease is characterized by the infiltration of inflammatory cells into the airways, resulting in the activation of proteolytic enzymes and proteinases, leading to the destruction of the alveolar structure (pulmonary emphysema). Pharmacological treatment involves the use of β2 adrenergic agonists, muscarinic receptor antagonists, phosphodiesterase-4 enzyme inhibitors, and corticosteroids, which do not prevent disease progression or reduce mortality.
This Special Issue aims to provide a space for the exploration of new therapies for the treatment of neuropathies, cancer pain, and inflammatory diseases of the respiratory tract, such as pulmonary emphysema.
Authors are invited to contribute with preclinical research articles and systematic reviews on the investigation of natural products for the treatment of chronic pain (neuropathies and cancer pain) and inflammation of the respiratory tract (pulmonary emphysema).
Prof. Dr. Fernanda Regina de Castro Almeida
Dr. Francisco De Assis Oliveira
Guest Editors
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Keywords
- natural products
- chronic pain
- neuropathies
- oncological pain
- anti-inflammatory activity
- pulmonary emphysema
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