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Biomedicines
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New Technologies in Digestive Endoscopy
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New Technologies in Digestive Endoscopy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7622

Special Issue Editor

Dr. Přemysl Falt

E-Mail Website
Guest Editor
2nd Internal Department, Gastroenterology and Geriatrics, University Hospital and Faculty of Medicine, Palacký University, Olomouc, Czech Republic
Interests: gastroenterology; therapeutic digestive endoscopy; pancreatobiliary endoscopy; colonoscopy; colorectal cancer; inflammatory bowel diseases; esophageal and small intestinal diseases; abdominal ultrasonography

Special Issue Information

Dear Colleagues,

Digestive endoscopy is a progressively evolving minimally invasive modality used in virtually all parts of the gastrointestinal tract. Recently, new technologies have been emerging to increase diagnostic and therapeutic yield and potentially improve patient prognosis. This Special Issue aims to provide an overview of some of the new technologies under research or already routinely used during endoscopy procedures. Potential topics for this Special Issue include new imaging modalities, possible applications of artificial intelligence, innovations in histopathological and cytological processing, in vivo tissue analysis technologies, molecular and genomic analysis, advances of endoscopic resection techniques and the evolving role of transluminal and capsule endoscopy.

Dr. Přemysl Falt
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestive endoscopy
  • gastrointestinal tract
  • artificial intelligence
  • histopathology
  • cytology
  • molecular imaging
  • genomic analysis
  • transluminal endoscopy
  • capsule endoscopy

Published Papers (5 papers)

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Research

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13 pages, 453 KiB  
Article
Intraluminal Therapy for Helicobacter pylori Infection—Comparison of Medicament Containing Tetracycline, Metronidazole, and Bismuth versus Amoxicillin, Metronidazole, and Clarithromycin: A Randomized Controlled Study
by Ting-Wen Liu, Yen-Po Chen, Cheng-Yu Ho, Ming-Jen Chen, Horng-Yuan Wang, Shou-Chuan Shih and Tai-Cherng Liou
Biomedicines 2023, 11(4), 1084; https://doi.org/10.3390/biomedicines11041084 - 3 Apr 2023
Cited by 1 | Viewed by 1556
Abstract
Helicobacter pylori (H. pylori) can be eradicated immediately via local application of single-dose medicament on endoscopic examination. In our previous report, “the eradication rate of intraluminal therapy for H. pylori infection (ILTHPI) is 53.7% (51/95) using medicament containing amoxicillin, metronidazole, and clarithromycin”. We [...] Read more.
Helicobacter pylori (H. pylori) can be eradicated immediately via local application of single-dose medicament on endoscopic examination. In our previous report, “the eradication rate of intraluminal therapy for H. pylori infection (ILTHPI) is 53.7% (51/95) using medicament containing amoxicillin, metronidazole, and clarithromycin”. We aimed to evaluate the efficacy and adverse events of medicament containing tetracycline, metronidazole, and bismuth and to improve the efficacy of stomach acid control before ILTHPI. After usage of dexlansoprazole (60 mg b.i.d.) or vonoprazan (20 mg q.d.) for 3 days before ILTHPI, 103 of 104 (99.1%) symptomatic H. pylori-infected treatment-naïve patients achieved levels of stomach pH ≥ 6. Patients were randomized to receive ILTHPI with medicaments containing tetracycline, metronidazole, and bismuth (Group A, n = 52) or amoxicillin, metronidazole, and clarithromycin (Group B, n = 52). The eradication rate of ILTHPI was similar between Group A (76.5%; 39/51) and Group B (84.6%, 44/52) (p = 0.427) and the adverse event was mild diarrhea (2.9%; 3/104). The eradication rate significantly increased from 53.7% (51/95) to 84.6% (44/52) after acid control (p = 0.0004) for Group B patients. The overall eradication rates of successful ILTHPI plus 7-day non-bismuth (Group A) or 7-day bismuth (Group B) oral quadruple therapy for ILTHPI failure patients were both excellent (96.1% for Group A and 98.1% for Group B). Full article
(This article belongs to the Special Issue New Technologies in Digestive Endoscopy)
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12 pages, 1527 KiB  
Article
Fluorescence In Situ Hybridization in Primary Diagnosis of Biliary Strictures: A Single-Center Prospective Interventional Study
by Vincent Dansou Zoundjiekpon, Premysl Falt, Jana Zapletalova, Petr Vanek, Daniela Kurfurstova, Zuzana Slobodova, Daniela Skanderova, Gabriela Korinkova, Pavel Skalicky, Martin Lovecek and Ondrej Urban
Biomedicines 2023, 11(3), 755; https://doi.org/10.3390/biomedicines11030755 - 2 Mar 2023
Cited by 1 | Viewed by 1464
Abstract
Background and aims: Diagnosis of the biliary stricture remains a challenge. In view of the low sensitivity of brush cytology (BC), fluorescence in situ hybridization (FISH) has been reported as a useful adjunctive test in patients with biliary strictures. We aimed to determine [...] Read more.
Background and aims: Diagnosis of the biliary stricture remains a challenge. In view of the low sensitivity of brush cytology (BC), fluorescence in situ hybridization (FISH) has been reported as a useful adjunctive test in patients with biliary strictures. We aimed to determine performance characteristics of BC and FISH individually and in combination (BC + FISH) in the primary diagnosis of biliary strictures. Methods: This single-center prospective study was conducted between April 2019 and January 2021. Consecutive patients with unsampled biliary strictures undergoing first endoscopic retrograde cholangiopancreatography in our institution were included. Tissue specimens from two standardized transpapillary brushings from the strictures were examined by routine cytology and FISH. Histopathological confirmation after surgery or 12-month follow-up was regarded as the reference standard for final diagnosis. Results: Of 109 enrolled patients, six were excluded and one lost from the final analysis. In the remaining 102 patients (60.8% males, mean age 67.4, range 25–92 years), the proportions of benign and malignant strictures were 28 (27.5%) and 74 (72.5%), respectively. The proportions of proximal and distal strictures were 26 (25.5%) and 76 (74.5%), respectively. In comparison to BC alone, FISH increased the sensitivity from 36.1% to 50.7% (p = 0.076) while maintaining similar specificity (p = 0.311). Conclusions: Dual-modality tissue evaluation using BC + FISH showed an improving trend in sensitivity for the primary diagnosis of biliary strictures when compared with BC alone. Full article
(This article belongs to the Special Issue New Technologies in Digestive Endoscopy)
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Review

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16 pages, 353 KiB  
Review
New Technologies in Digestive Endoscopy for Ulcerative Colitis Patients
by Paolo Biamonte, Ferdinando D’Amico, Ernesto Fasulo, Rukaia Barà, Francesca Bernardi, Mariangela Allocca, Alessandra Zilli, Silvio Danese and Federica Furfaro
Biomedicines 2023, 11(8), 2139; https://doi.org/10.3390/biomedicines11082139 - 29 Jul 2023
Cited by 2 | Viewed by 1518
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease primarily affecting the colon and rectum. Endoscopy plays a crucial role in the diagnosis and management of UC. Recent advancements in endoscopic technology, including chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and the use of artificial [...] Read more.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease primarily affecting the colon and rectum. Endoscopy plays a crucial role in the diagnosis and management of UC. Recent advancements in endoscopic technology, including chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and the use of artificial intelligence, have revolutionized the assessment and treatment of UC patients. These innovative techniques enable early detection of dysplasia and cancer, more precise characterization of disease extent and severity and more targeted biopsies, leading to improved diagnosis and disease monitoring. Furthermore, these advancements have significant implications for therapeutic decision making, empowering clinicians to carefully consider a range of treatment options, including pharmacological therapies, endoscopic interventions and surgical approaches. In this review, we provide an overview of the latest endoscopic technologies and their applications for diagnosing and monitoring UC. We also discuss their impact on treatment decision making, highlighting the potential benefits and limitations of each technique. Full article
(This article belongs to the Special Issue New Technologies in Digestive Endoscopy)

Other

Jump to: Research, Review

24 pages, 1541 KiB  
Systematic Review
Enteroscopy versus Video Capsule Endoscopy for Automatic Diagnosis of Small Bowel Disorders—A Comparative Analysis of Artificial Intelligence Applications
by Stefan Lucian Popa, Bogdan Stancu, Abdulrahman Ismaiel, Daria Claudia Turtoi, Vlad Dumitru Brata, Traian Adrian Duse, Roxana Bolchis, Alexandru Marius Padureanu, Miruna Oana Dita, Atamyrat Bashimov, Victor Incze, Edoardo Pinna, Simona Grad, Andrei-Vasile Pop, Dinu Iuliu Dumitrascu, Mihai Alexandru Munteanu, Teodora Surdea-Blaga and Florin Vasile Mihaileanu
Biomedicines 2023, 11(11), 2991; https://doi.org/10.3390/biomedicines11112991 - 7 Nov 2023
Viewed by 1002
Abstract
Background: Small bowel disorders present a diagnostic challenge due to the limited accessibility of the small intestine. Accurate diagnosis is made with the aid of specific procedures, like capsule endoscopy or double-ballon enteroscopy, but they are not usually solicited and not widely accessible. [...] Read more.
Background: Small bowel disorders present a diagnostic challenge due to the limited accessibility of the small intestine. Accurate diagnosis is made with the aid of specific procedures, like capsule endoscopy or double-ballon enteroscopy, but they are not usually solicited and not widely accessible. This study aims to assess and compare the diagnostic effectiveness of enteroscopy and video capsule endoscopy (VCE) when combined with artificial intelligence (AI) algorithms for the automatic detection of small bowel diseases. Materials and methods: We performed an extensive literature search for relevant studies about AI applications capable of identifying small bowel disorders using enteroscopy and VCE, published between 2012 and 2023, employing PubMed, Cochrane Library, Google Scholar, Embase, Scopus, and ClinicalTrials.gov databases. Results: Our investigation discovered a total of 27 publications, out of which 21 studies assessed the application of VCE, while the remaining 6 articles analyzed the enteroscopy procedure. The included studies portrayed that both investigations, enhanced by AI, exhibited a high level of diagnostic accuracy. Enteroscopy demonstrated superior diagnostic capability, providing precise identification of small bowel pathologies with the added advantage of enabling immediate therapeutic intervention. The choice between these modalities should be guided by clinical context, patient preference, and resource availability. Studies with larger sample sizes and prospective designs are warranted to validate these results and optimize the integration of AI in small bowel diagnostics. Conclusions: The current analysis demonstrates that both enteroscopy and VCE with AI augmentation exhibit comparable diagnostic performance for the automatic detection of small bowel disorders. Full article
(This article belongs to the Special Issue New Technologies in Digestive Endoscopy)
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15 pages, 1811 KiB  
Systematic Review
Hybrid Argon Plasma Coagulation for Barrett’s Esophagus and for Colonic Mucosal Resection—A Systematic Review and Meta-Analysis
by Maria Manuela Estevinho, Rolando Pinho, João Carlos Silva, João Correia, Pedro Mesquita and Teresa Freitas
Biomedicines 2023, 11(4), 1139; https://doi.org/10.3390/biomedicines11041139 - 10 Apr 2023
Viewed by 1440
Abstract
Hybrid argon plasma coagulation (hAPC) is a novel technique that combines conventional argon plasma coagulation and waterjet submucosal expansion. The aims of this metanalysis were to evaluate the efficacy and safety of hAPC in the setting of Barret’s esophagus (BE) ablation and as [...] Read more.
Hybrid argon plasma coagulation (hAPC) is a novel technique that combines conventional argon plasma coagulation and waterjet submucosal expansion. The aims of this metanalysis were to evaluate the efficacy and safety of hAPC in the setting of Barret’s esophagus (BE) ablation and as an adjunct to colonic endoscopic mucosal resection (EMR). Four electronic databases were searched, and the results were analyzed by two independent authors. Random-effects meta-analyses of the proportions of endoscopic and histologic remission (for BE), recurrence, and post-procedure adverse events were performed using R. Studies’ reporting quality was also assessed. From the 979 identified records, 13 studies were included (10 regarding BE and three colonic EMR). The pooled percentages of endoscopic and histologic remission after hAPC for BE were 95% (95% confidence interval [CI] 91–99, I2 = 34) and 90% (95%CI 84–95, I2 = 46), respectively, while major adverse events and recurrence were registered in 2% (95%CI 0–5, I2 = 41) and 11% (95%CI 2–27, I2 = 11), respectively. Concerning hAPC-assisted EMR, the pooled percentages of major adverse events and recurrence were 5% (95%CI 2–10, I2 = 0) and 1% (95%CI 0–3, I2 = 40). Evidence suggests that the main advantages of hAPC are the increase in safety in the setting of BE ablation and the reduction of local recurrence after colonic EMR. Trials comparing hAPC with standard strategies are required to support its use for these indications. Full article
(This article belongs to the Special Issue New Technologies in Digestive Endoscopy)
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