Advanced Research in Epithelial–Mesenchymal Transition (EMT) in Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 927
Special Issue Editor
2. Department of Surgery, University Hospital of Patras, Rion, Greece
Interests: molecular biology of breast cancer; epithelial–mesenchymal transition (EMT); Hippo pathway; integrin-linked kinase (ILK)
Special Issue Information
Dear Colleagues,
A typical PubMed query using the search term “epithelial–mesenchymal transition” (“EMT”) retrieves over 48.000 articles, a number that is indicative of the great interest in this topic. EMT is a reversible transdifferentiation program whereby epithelial cells acquire the invasive, migratory mesenchymal phenotype. EMT normally occurs during embryonic development, as well as in wound healing as a physiological response to injury. This embryonic genetic program is hijacked by cancer cells for their own benefit, favoring the acquisition of metastatic capacity and resistance to therapy. Initially considered to be an on–off phenomenon, EMT is now viewed as a gradual transformation process that also produces epithelial–mesenchymal hybrids through partial EMT. Once the metastatic cells that have undergone EMT reach the site of distant metastasis, they are believed to undergo the reverse process of mesenchymal–epithelial transition (MET) in order to increase their proliferative capacity and facilitate metastatic outgrowth. Thus, cancer cells through EMT/MET processes acquire cellular plasticity and the ability to interconvert between intermediate epithelial–mesenchymal cell states in order to fulfill the various spatial and temporal requirements during the course of malignant progression and metastasis. Importantly, except from motility and invasion, EMT has been associated with chemoresistance, cancer stem cell properties, resistance to apoptosis, genomic instability, and metabolic reprogramming.
In this Special Issue, we welcome the submission of both original research and review articles focused on the latest progress and recent findings in all aspects of cancer-related EMT.
Dr. Ioanna Akrida
Guest Editor
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Keywords
- epithelial–mesenchymal transition (EMT)
- mesenchymal–epithelial transition (MET)
- epithelial–mesenchymal plasticity (EMP)
- tumor microenvironment
- cell–extracellular matrix interactions
- extracellular matrix remodeling
- metastasis
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