Stemness and Differentiation: A Systemic View

During recent years, several studies have demonstrated the key role of the metabolic network in the regulation of gene and epigenetic patterns in the course of self-renewal and differentiation processes. The impact of metabolomics on the remodeling of chromatin and on the regulation of epigenetic expression represents a current topic with new challenges for modern cell biology. In future, more emphasis should be given to the complexity elements linking network hubs during genetic, epigenetic, and metabolic rewiring that accompanies the various steps of cell differentiation. This Special Issue invites original research papers and reviews that cover both modeling and significant experimental advances in uncovering the relationships among the three key networks of life, namely, the metabolic, genetic, and epigenetic networks.

Prof. Dr. Roberto Zivieri
Dr. Nicola Pacini
Guest Editors

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