Proteomics of Extremophiles

Dear Colleagues,

Current knowledge about extremophiles includes a wide variety of prokaryotes and eukaryotes across a large range of environments characterized by hostile living conditions. They exhibit not only great flexibility for thriving under the most life-threatening habitats on Earth but can also survive the harsh conditions of space, which are completely inhospitable to the majority of organisms. As a result, extremophiles’ systems biology, their stress resistance and biochemical adaptation, are currently very much in the focus of microbiology, astrobiology, and biotechnology.

The proteomic investigation of extremophiles has proved to be a powerful tool to explore the physiology and pathways of key proteins, which are possibly involved in tolerance formation to stressful living conditions, in view of climate change and the progressive interest for extraterrestrial microbial activities and resistance against cosmic radiation. The molecular uniqueness and the biotechnological potential of species from the extremes of life have also driven an intense activity of proteomics research aimed at screening for novel proteins and enzymes offering advantages over those from less-tolerant counterparts. Along with unravelling adaptive mechanisms, proteomics of extremophiles holds the potential to contribute to the development of strategies at the gene and protein level ultimately leading to biotechnological innovations.

This Special Issue welcomes submissions of original research and review manuscripts focusing on the application of proteomics to answer questions concerning the adaptation biology of extremophiles and to explore the molecular basis of protein stability and activity and post-translational modifications at extreme values of physicochemical parameters. The ultimate goal is to achieve a precise overview of this novel and interdisciplinary field of microbiology, providing information about the current status of this emerging and promising field of research.

Dr. Gorji Marzban
Dr. Donatella Tesei
Guest Editors

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• strategies in protein sample preparation
• fungal extremophiles
• environmental changes
• stress survival and adaption
• evolution biology
• extreme habitats
• proteomics of extremophiles
• extremophile enzymes and biotechnology