Special Issue "Proteomics and Bioinformatics MultiOmics Applications towards New and Personalized Therapies Using Quantitative and Treatment-Specific Proteome Signatures, Quantitative Clinical End Points and Biomarkers Identification"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Proteomics".

Deadline for manuscript submissions: 17 July 2020.

Special Issue Editors

Dr. Piero Ricchiuto
Website
Guest Editor
Principal Scientist Bioinformatics, AstraZeneca, The Darwin Building, 310 Milton Rd, Milton, Cambridge CB4 0WG, UK
Interests: Proteomics & Transcriptomics obtained from human clinical samples in rare diseases; novel algorithms from protein-protein identification; novel algorithms for peptides to protein identification; thermal protein profiles; clinical data and diagnostic companions; CT- scans and clinical imaging used for patients stratification
Dr. Massimiliano Gaetani
Website
Guest Editor
Head of the Chemical Proteomics Core Facility, Karolinska Institutet, Department of Medical Biochemistry and Biophysics (MBB), Biomedicum Building, SE 17177 Stockholm, Sweden
Interests: mass spectrometry-based quantitative proteomics, chemical proteomics, target deconvolution, mechanis of action, protein solubility/stability alteration, PISA, drug development, repurposing strategies, proteomics driven personalized therapies

Special Issue Information

Dear Colleagues,

Mass spectrometry (MS) based Proteomics involves the separation, identification, quantification and functional characterization of the entire protein profile of a given cell, tissue, and/or organism. Proteomics is used to study how proteins adapt and modify their expression as well as their function in a particular biological pathway or respond to a compound or treatment. Recent advances in MS have allowed proteomes to be studied in depth, with high throughput strategies and protocols producing long lists of proteins. Ergo, a boost of analytical DDA (Data Dependent Acquisition) and DIA (Data Independent Acquisition) methods for protein identification and quantification are being developed to increase the precision of methods which identify proteins within a sample. Recent high throughput chemical proteomics strategies can enable more biological replicates and provide orthogonal approaches for deconvolution of targets and MoA. The latest advances in bioinformatics have also been applied to proteomics data allowing the output to be analysed and relevant biological information to be specifically deconvoluted.

This issue is focused to original research that uses bioinformatics, mass spectrometry and proteomics tools integrated with multi-omics framework(s) aimed to the study of properties and interactions of proteins, protein structure and post-translational modifications, binding site and epitope identification, biomarker discovery in the context of human diseases.
Moreover, papers with focus on life threatening and rare haematological human diseases and repurposing strategies aided by proteomics and bioinformatics approaches are of particular interest.
This issue aims to provide the scientific community from bench scientists to clinicians a direct translational approach from basic science to meaningful explorative or actual end points of clinical trials of rare and life threatening diseases.

Dr. Piero Ricchiuto
Dr. Massimiliano Gaetani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarker identification
  • target deconvolution
  • mechanism of action
  • off-targets
  • rare disease
  • hematological disease
  • life-threatening disease
  • chemical proteomics
  • personalized therapies
  • clinical exploratory end points
  • multi-omics tools
  • good practices in clinical proteomics
  • application of AI & Bayesian models in quantitative proteomics
  • F.A.I.R. data

Published Papers

This special issue is now open for submission.
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