Deciphering the Process and Mechanisms of Virus Infection in Host Cells

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Infection Biology".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1551

Special Issue Editor


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Guest Editor
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Interests: virus receptor; virus and host interaction; mechanism of virus entry; host factor; vaccine

Special Issue Information

Dear Colleagues,

Viruses continue to pose an increasing threat worldwide. Viral pandemics are causing severe diseases in humans and significant commercial losses. However, the processes and mechanisms of virus infection remain largely unknown, thus greatly impeding the development of drugs, vaccines, and strategies for virus control.

We are delighted to extend an invitation to you to publish your latest research in our Special Issue, which aims to further decipher the processes and mechanisms implicated in virus infection in host cells.

In this Special Issue, we welcome original research articles and reviews covering a wide range of topics, including, but not limited to, the following: the mechanisms of virus infection and pathology, the virus life cycle, virus genetics and evolution, and virus–host interactions.

We look forward to receiving your contributions.

Dr. Xin Zhao
Guest Editor

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Keywords

  • virus
  • pathology
  • virus–host interaction
  • host factor
  • receptor
  • entry
  • life cycle

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Published Papers (1 paper)

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Research

13 pages, 2940 KiB  
Article
IAV Antagonizes Host Innate Immunity by Weakening the LncRNA-LRIR2-Mediated Antiviral Functions
by Na Chen and Baoge Zhang
Biology 2024, 13(12), 998; https://doi.org/10.3390/biology13120998 - 1 Dec 2024
Viewed by 1168
Abstract
A growing number of studies have shown that long non-coding RNAs (lncRNAs) are implicated in many biological processes, including the regulation of innate immunity and IAV replication. In addition, IAV has been found to be able to hijack lncRNAs and thus antagonize host [...] Read more.
A growing number of studies have shown that long non-coding RNAs (lncRNAs) are implicated in many biological processes, including the regulation of innate immunity and IAV replication. In addition, IAV has been found to be able to hijack lncRNAs and thus antagonize host innate immunity. Nonetheless, whether IAV can antagonize host innate immunity by weakening the antiviral functions mediated by lncRNAs is unknown. In this study, we found that LncRNA-ENST00000491430 regulates IAV replication and named it LRIR2. Interestingly, we found that the expression of LRIR2 was suppressed during IAV infection. Importantly, LRIR2 overexpression inhibited IAV replication, suggesting that LRIR2 plays an antiviral role during IAV infection. Mechanistically, we demonstrated that LRIR2 inhibits the transcription and replication of the IAV genome. In addition, the antiviral function of LRIR2 is mainly dependent on the stem-loop structures of 1–118 nt and 575–683 nt. Taken together, IAV could antagonize host innate immunity by weakening the LncRNA-LRIR2-mediated antiviral functions. Our study provides novel perspectives into viral strategies to antagonize host innate immunity. It lays a theoretical foundation for the design of novel anti-IAV drugs that target host lncRNAs or the antagonism effect. Full article
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