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Biology
Special Issues
Mechanobiology 2.0
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Mechanobiology 2.0

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 4158

Special Issue Editor

Dr. Tae-Jin Kim

E-Mail Website
Guest Editor
Department of Biological Sciences, Pusan National University, Pusan 46241, Republic of Korea
Interests: mechanobiology; cell–cell communication; cell–ECM interaction; FRET imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The field of mechanobiology has recently emerged at the interface of biology, medicine, biophysics, and bioengineering. In general, it refers to the study of how biological components such as cells, tissues, and organs perceive and respond to mechanical cues to regulate various biological processes, such as development, differentiation, physiology, and disease.

This Special Issue aims to gather and present original reports, scientific articles, communications, and reviews discussing the latest advances in the field of mechanobiology in all its facets. Topics include, but are not limited to, the following: mechanobiology in stem cells; mechanobiology in cancer; mechanobiology in physiology; mechanobiology in the nucleus (e.g., nuclear mechanics, gene/genome regulation); mechanobiology in tissue development and homeostasis; mechanobiology in health and disease; mechanobiology in plants; cellular mechanosensing, mechanotransduction, and mechanoresponse; biomechanics; innovative approaches to mechanobiology research.

Dr. Tae-Jin Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanotransduction
  • mechanical cues
  • biomechanics
  • tissue engineering
  • mechanosensitive channels
  • mechanical signals
  • extracellular matrix
  • stem cells
  • biomaterial diseases

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Published Papers (2 papers)

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Research

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13 pages, 9254 KiB  
Article
Visualization of Cell Membrane Tension Regulated by the Microfilaments as a “Shock Absorber” in Micropatterned Cells
by Xianmeng Wang, Na Li, Zhengyao Zhang, Kairong Qin, Hangyu Zhang, Shuai Shao and Bo Liu
Biology 2023, 12(6), 889; https://doi.org/10.3390/biology12060889 - 20 Jun 2023
Cited by 1 | Viewed by 2031
Abstract
The extracellular stress signal transmits along the cell membrane–cytoskeleton–focal adhesions (FAs) complex, regulating the cell function through membrane tension. However, the mechanism of the complex regulating membrane tension is still unclear. This study designed polydimethylsiloxane stamps with specific shapes to change the actin [...] Read more.
The extracellular stress signal transmits along the cell membrane–cytoskeleton–focal adhesions (FAs) complex, regulating the cell function through membrane tension. However, the mechanism of the complex regulating membrane tension is still unclear. This study designed polydimethylsiloxane stamps with specific shapes to change the actin filaments’ arrangement and FAs’ distribution artificially in live cells, visualized the membrane tension in real time, and introduced the concept of information entropy to describe the order degree of the actin filaments and plasma membrane tension. The results showed that the actin filaments’ arrangement and FAs’ distribution in the patterned cells were changed significantly. The hypertonic solution resulted in the plasma membrane tension of the pattern cell changing more evenly and slowly in the zone rich in cytoskeletal filaments than in the zone lacking filaments. In addition, the membrane tension changed less in the adhesive area than in the non-adhesive area when destroying the cytoskeletal microfilaments. This suggested that patterned cells accumulated more actin filaments in the zone where FAs were difficult to generate to maintain the stability of the overall membrane tension. The actin filaments act as shock absorbers to cushion the alternation in membrane tension without changing the final value of membrane tension. Full article
(This article belongs to the Special Issue Mechanobiology 2.0)
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Review

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19 pages, 2110 KiB  
Review
Mechanobiological Approach for Intestinal Mucosal Immunology
by Hyeyun Kim, Se-Hui Lee and Jin-Young Yang
Biology 2025, 14(2), 110; https://doi.org/10.3390/biology14020110 - 22 Jan 2025
Viewed by 1099
Abstract
The intestinal area is composed of diverse cell types that harmonize gut homeostasis, which is influenced by both endogenous and exogenous factors. Notably, the environment of the intestine is exposed to several types of mechanical forces, including shear stress generated by fluid flow, [...] Read more.
The intestinal area is composed of diverse cell types that harmonize gut homeostasis, which is influenced by both endogenous and exogenous factors. Notably, the environment of the intestine is exposed to several types of mechanical forces, including shear stress generated by fluid flow, compression and stretch generated by luminal contents and peristaltic waves of the intestine, and stiffness attributed to the extracellular matrix. These forces play critical roles in the regulation of cell proliferation, differentiation, and migration. Many efforts have been made to simulate the actual intestinal environment in vitro. The three-dimensional organoid culture system has emerged as a powerful tool for studying the mechanism of the intestinal epithelial barrier, mimicking rapidly renewing epithelium from intestinal stem cells (ISCs) in vivo. However, many aspects of how mechanical forces, such as shear stress, stiffness, compression, and stretch forces, influence the intestinal area remain unresolved. Here, we review the recent studies elucidating the impact of mechanical forces on intestinal immunity, interaction with the gut microbiome, and intestinal diseases. Full article
(This article belongs to the Special Issue Mechanobiology 2.0)
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