Mechanobiology 2.0

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2481

Special Issue Editor


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Guest Editor
Department of Biological Sciences, Pusan National University, Pusan 46241, Republic of Korea
Interests: mechanobiology; cell–cell communication; cell–ECM interaction; FRET imaging
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Special Issue Information

Dear Colleagues, 

The field of mechanobiology has recently emerged at the interface of biology, medicine, biophysics, and bioengineering. In general, it refers to the study of how biological components such as cells, tissues, and organs perceive and respond to mechanical cues to regulate various biological processes, such as development, differentiation, physiology, and disease.

This Special Issue aims to gather and present original reports, scientific articles, communications, and reviews discussing the latest advances in the field of mechanobiology in all its facets. Topics include, but are not limited to, the following: mechanobiology in stem cells; mechanobiology in cancer; mechanobiology in physiology; mechanobiology in the nucleus (e.g., nuclear mechanics, gene/genome regulation); mechanobiology in tissue development and homeostasis; mechanobiology in health and disease; mechanobiology in plants; cellular mechanosensing, mechanotransduction, and mechanoresponse; biomechanics; innovative approaches to mechanobiology research.

Dr. Tae-Jin Kim
Guest Editor

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Keywords

  • mechanotransduction
  • mechanical cues
  • biomechanics
  • tissue engineering
  • mechanosensitive channels
  • mechanical signals
  • extracellular matrix
  • stem cells
  • biomaterial diseases

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Published Papers (1 paper)

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Research

13 pages, 9254 KiB  
Article
Visualization of Cell Membrane Tension Regulated by the Microfilaments as a “Shock Absorber” in Micropatterned Cells
by Xianmeng Wang, Na Li, Zhengyao Zhang, Kairong Qin, Hangyu Zhang, Shuai Shao and Bo Liu
Biology 2023, 12(6), 889; https://doi.org/10.3390/biology12060889 - 20 Jun 2023
Cited by 1 | Viewed by 1666
Abstract
The extracellular stress signal transmits along the cell membrane–cytoskeleton–focal adhesions (FAs) complex, regulating the cell function through membrane tension. However, the mechanism of the complex regulating membrane tension is still unclear. This study designed polydimethylsiloxane stamps with specific shapes to change the actin [...] Read more.
The extracellular stress signal transmits along the cell membrane–cytoskeleton–focal adhesions (FAs) complex, regulating the cell function through membrane tension. However, the mechanism of the complex regulating membrane tension is still unclear. This study designed polydimethylsiloxane stamps with specific shapes to change the actin filaments’ arrangement and FAs’ distribution artificially in live cells, visualized the membrane tension in real time, and introduced the concept of information entropy to describe the order degree of the actin filaments and plasma membrane tension. The results showed that the actin filaments’ arrangement and FAs’ distribution in the patterned cells were changed significantly. The hypertonic solution resulted in the plasma membrane tension of the pattern cell changing more evenly and slowly in the zone rich in cytoskeletal filaments than in the zone lacking filaments. In addition, the membrane tension changed less in the adhesive area than in the non-adhesive area when destroying the cytoskeletal microfilaments. This suggested that patterned cells accumulated more actin filaments in the zone where FAs were difficult to generate to maintain the stability of the overall membrane tension. The actin filaments act as shock absorbers to cushion the alternation in membrane tension without changing the final value of membrane tension. Full article
(This article belongs to the Special Issue Mechanobiology 2.0)
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