Targeting Sphingolipids for Cancer Therapy
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 March 2027 | Viewed by 121
Special Issue Editor
Interests: sphingolipid metabolism, metabolic disease; liver cancer; obesity; non-alcoholic fatty liver disease
Special Issue Information
Dear Colleagues,
Bioactive sphingolipid metabolites, such as ceramides and sphingosine-1-phosphate, play critical roles in the development and progression of cancer. Recent advances have demonstrated that altering multiple branches of the sphingolipid metabolic pathway can inhibit cancer cell proliferation and reduce tumor burden. This Special Issue, “Targeting Sphingolipids for Cancer Therapy”, will explore how the modulation of sphingolipid metabolism in both the tumor and the tumor microenvironment represents a promising strategy in cancer therapy.
This Special Issue will focus on molecular mechanisms and therapeutic targets in the sphingolipid metabolic pathway that affect cancer biology. We aim to highlight recent discoveries that leverage the targeting and regulation of key sphingolipid enzymes, receptors, and transporters to influence cancer. As integrating findings from multiple fields is crucial in advancing therapeutics, we welcome molecular, genetic, pharmacological, and bioinformatic approaches that contribute to identifying and demonstrating potential for clinical applications.
Specifically, we welcome articles and reviews on the following themes:
- Molecular mechanisms of sphingolipids in tumor initiation and cell proliferation;
- Genetic and pharmacological approaches inducing or enhancing sphingolipid metabolism with effects on tumor development;
- Computational bioinformatic analyses uncovering sphingolipid metabolic genes associated with cancer;
- Studies targeting sphingolipids within the tumor microenvironment, particularly immune cells and fibroblasts.
By promoting research from diverse fields with different methodologies, this Special Issue will advance our knowledge of sphingolipid‑driven mechanisms with potentially promising targets for cancer therapeutics.
We look forward to receiving your contributions.
Dr. Christopher Daniel Green
Guest Editor
Manuscript Submission Information
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Keywords
- sphingolipids
- lipid
- cancer
- therapeutics
- sphingosine-1-phosphate
- ceramide
- tumor microenvironment
- metastasis
- tumor growth
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