Diabetes and Cardiovascular Diseases in the New Era

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 2801

Special Issue Editors


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Guest Editor
Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa
Interests: diabetes mellitus; coronay artery disease; inflammation; oxidative stress; coagulation

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Guest Editor
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Gauteng 0028, South Africa
Interests: molecular mechanisms; genetics; coronary heart disease; diabetes; cholesterol

Special Issue Information

Dear Colleagues,

Diabetes and cardiovascular disease (CVD) are interconnected pathologies with shared molecular underpinnings, including metabolic dysregulation, chronic inflammation, and endothelial dysfunction. Recent advances in molecular biology, genetics, and systems biology have unveiled intricate mechanisms driving diabetes-associated cardiovascular complications, from alterations in lipid metabolism to epigenetic modifications and oxidative stress pathways.

This Special Issue, Diabetes and Cardiovascular Disease in the New Era, invites original research and review articles exploring fundamental biological mechanisms underlying diabetic CVD. We welcome studies investigating molecular signaling networks, emerging biomarkers, metabolic reprogramming, vascular remodeling, and immune dysregulation in the diabetic heart and vasculature. Additionally, contributions leveraging cutting-edge technologies such as single-cell sequencing, transcriptomics, and computational modeling used to elucidate disease progression are highly encouraged.

By fostering research at the intersection of diabetes and cardiovascular pathophysiology, this Special Issue aims to advance our mechanistic understanding and pave the way for future translational breakthroughs. We look forward to your valuable contributions that will enhance knowledge in this rapidly evolving field.

Dr. Prashilla Soma
Prof. Dr. Alisa Phulukdaree
Guest Editors

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Keywords

  • metabolic dysregulation
  • endothelial dysfunction
  • inflammation
  • immune response
  • molecular signaling pathways
  • oxidative stress and vascular remodeling

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Published Papers (1 paper)

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Review

22 pages, 1392 KB  
Review
Chronopharmacology-Driven Precision Therapies for Time-Optimized Cardiometabolic Disease Management
by Shakta Mani Satyam, Sainath Prabhakar, Mohamed El-Tanani, Bhoomendra Bhongade, Adil Farooq Wali, Imran Rashid Rangraze, Ismail Ibrahim Ali Matalka, Yahia El-Tanani, Manfredi Rizzo, Sorina Ispas, Ioannis Ilias, Anna Paczkowska, Viviana Maggio and Karolina Hoffmann
Biology 2026, 15(3), 241; https://doi.org/10.3390/biology15030241 - 28 Jan 2026
Cited by 2 | Viewed by 2226
Abstract
Cardiometabolic diseases, including hypertension, type 2 diabetes, dyslipidemia, and obesity, along with their cardiovascular complications, remain leading causes of morbidity and mortality worldwide, imposing significant public health, economic, and societal burdens. Conventional pharmacological therapies often show limited efficacy and increased adverse effects because [...] Read more.
Cardiometabolic diseases, including hypertension, type 2 diabetes, dyslipidemia, and obesity, along with their cardiovascular complications, remain leading causes of morbidity and mortality worldwide, imposing significant public health, economic, and societal burdens. Conventional pharmacological therapies often show limited efficacy and increased adverse effects because they do not account for the body’s intrinsic circadian rhythms, which regulate organ function, drug absorption, and metabolism. Chronopharmacology, which aligns treatment timing with these biological rhythms, offers a strategy to enhance therapeutic outcomes. This review presents a comprehensive analysis of chronopharmacology principles applied to cardiometabolic disease management, integrating molecular, physiological, and clinical perspectives. It examines how core clock genes and tissue-specific circadian patterns influence drug action and absorption and summarizes evidence-based time-optimized interventions for hypertension, diabetes, dyslipidemia, obesity, and multimorbid patients. Furthermore, the review highlights emerging innovations, including artificial intelligence-guided dosing, circadian-biomarker-informed therapy selection, and wearable digital devices for real-time monitoring of biological rhythms. By synthesizing mechanistic and clinical insights, circadian-aligned treatment strategies are shown to improve drug efficacy, reduce adverse effects, and support the development of precision, rhythm-based therapeutics, offering a practical framework for personalized cardiometabolic disease care. Full article
(This article belongs to the Special Issue Diabetes and Cardiovascular Diseases in the New Era)
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