Atherosclerosis, Ageing and Lipid Metabolism: From Gene to Phenotype to Integrated Analysis
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 397
Special Issue Editors
Interests: lipoprotein metabolism; lipid metabolism; bile acid metabolism; liver; atherosclerosis; NAFLD; cardiometabolic diseases
Special Issues, Collections and Topics in MDPI journals
Interests: cardiometabolic diseases; autophagy; genetic; atherosclerosis; lipoprotein metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lifestyle interventions and pharmacological treatment—including lipid-lowering, anti-diabetic, anti-hypertensive and anti-thrombotic interventions—are an unquestionable and major success in modern medicine, contributing to the worldwide increase of life expectancy by preventing cardiometabolic disease. However, aging populations represent a major challenge for healthcare providers, since they expose a major limitation of the current strategies for cardiometabolic diseases management in the elderly. Epidemiological studies have shown the complex and age-driven etiology of cardiometabolic diseases by identifying many risk factors. Genetics has a key role in cardiometabolic diseases by affecting composition and functionality of lipoproteins, intracellular lipid metabolism, and inflammation. Translational research has been very successful in the creation of multidisciplinary approach to the understanding of cardiometabolic diseases. Unfortunately, pathobiological research has not been equally successful in translating biological insights into prevention, diagnosis, and treatment of human diseases. The limited amount of success can be explained by the gaps between clinically relevant questions, preclinical models, and technologies, as well as by conventional reductionist approaches. Future research strategies should create the basis for shifting healthcare management of cardiometabolic disease from diagnosis and treatment to prevention. An integrated approach (e.g., network medicine), with a coordinated, unifying, multidisciplinary platform which includes genomic, epigenomic, molecular, and clinical data will enable a more efficient understanding of how the pathogenic processes underlying cardiometabolic diseases and lead to a better comprehension of the driver for healthy aging across the life course.
This Special Issue welcomes the submission of original research and review manuscripts on prevention, diagnosis, and therapy of cardiometabolic diseases focusing on aging, lipoprotein and intracellular lipid metabolism, and integrated approach of the different omics analyses The overall aim of the Special Issue is to achieve a realistic overview of this exciting and interdisciplinary field of biomedical research on cardiometabolic diseases.
Prof. Dr. Paolo Parini
Prof. Dr. Ewa Ehrenborg
Prof. Dr. Mats Eriksson
Guest Editors
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Keywords
- aging
- autophagy
- atherosclerosis
- cardiometabolic diseases
- epigenomic
- genomic
- GWAS
- lipid
- lipoprotein metabolism
- metabolomic
- metagenomic network medicine
- proteomic
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