Special Issue "Low Template DNA: New Trends in Genotyping"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Eduardo Arroyo Pardo
E-Mail Website
Guest Editor
Legal Medicine, Psyquiatry and Pathology, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: ancient ADN; populational genetics; genetic polymorphism; STRs; mtDNA; Y-chromosome

Special Issue Information

Dear Colleagues,

DNA is a molecule that can endure for long periods under adverse environmental conditions. This has been shown since the early 1990s, when the possibility of recovering DNA from degraded samples became a promising technique for paleontology, archaeology, zoology, microbiology, and even forensics. In many situations within these fields, degraded and/or scarce DNA could be isolated, amplified, and sequenced applying specific protocols for very degraded genetic material. Results could shed light on problems that could not otherwise be resolved. Laboratory protocols, implemented according to the circumstances and the special biochemistry of degraded DNA, also helped to detect possible contamination with exogen DNA. In the last decade, however, a new generation of sequencing platforms has been developed. These new strategies can sequence in parallel thousands or even millions of DNA fragments from a given biological sample, from forensic remains, or traces of microorganisms from the soil. The sequencing data should at this point be assembled through specific algorithms executed by powerful computers, thus carrying DNA typing to a new frontier.

The Special Issue welcomes short communications, reviews, or original articles where new research casework or laboratory strategies for degraded and/or scarce DNA typing are shown. The scope ranges from human identification of forensic remains to microorganism metagenomics, and from ancient DNA typing of extinct species to diagnosis of diseases from the past.

Dr. Eduardo Arroyo Pardo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • low template DNA
  • contaminating DNA
  • PCR inhibitors
  • human identification
  • ancient DNA
  • new strategies of genotyping
  • populations of the past
  • archaeogenetics
  • forensic genetics
  • metagenomics

Published Papers

This special issue is now open for submission.
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