Kinases in Virus Biology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 382
Special Issue Editor
Special Issue Information
Dear Colleagues,
Kinase enzymes are key facilitators of fundamental biological processes, with phosphorylation of proteins and lipids regulating the activity of diverse cell signalling pathways. During virus infection, kinase enzymes function as a critical nexus, stimulating many different events that influence pathogenesis. Host cells defend themselves from viruses via activation of kinases to drive pathogen recognition and antiviral signalling. Viruses may usurp kinase activity to phosphorylate their own or host proteins, conferring pathogenic functions and promoting replication. Kinase enzymes encoded by some viruses may regulate latency and reactivation of persistent infections. Viruses have been demonstrated to “steal” host kinase proto-oncogenes, modifying them to acutely promote cell transformation and cancer. Additionally, inhibitors of kinase function have been demonstrated to be a promising avenue for antiviral therapeutic development.
This Special Issue aims to highlight recent scientific advances that feature the role of kinases in viral infection. Submission of original research manuscripts, short communications, and definitive reviews is welcome from researchers in diverse biomedical fields. We encourage contribution of articles pertaining to topics as diverse as antiviral discovery, viral influence on cell signalling events, viral phosphoproteins, viruses and cancer, innate immune defences, regulation of viral replication, and other processes reliant on phosphorylation. Our aim is to showcase underlying themes in viral interactions with kinase processes, in the hope of inspiring insights that cross disciplines and stimulate new collaborations among interested researchers.
Dr. Justin Roby
Guest Editor
Manuscript Submission Information
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Keywords
- virus
- kinase
- phosphorylation
- cell signaling
- innate immunity
- pathogenesis
- antiviral
- antagonism
- cancer
- virus–host interaction
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