Special Issue "10th Anniversary of Biology—Innate Immune System: Insights from Zebrafish Models"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (30 January 2023) | Viewed by 915

Special Issue Editors

Dr. Monica Varela
E-Mail Website
Guest Editor
Institute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
Interests: inflammation; cell death; host–pathogen interactions; inflammasomes; macrophages; live-imaging; zebrafish
Dr. Gabriel Forn-Cuní
E-Mail Website
Guest Editor
Institute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
Interests: host–pathogen interaction; zebrafish models; infectious diseases; innate immunity; inflammation

Special Issue Information

Dear Colleagues,

The year 2021 marks the 10th anniversary of Biology, a peer-reviewed open access journal on biological sciences. Biology has published more than 1200 papers from more than 8300 authors. We are grateful to every author, reviewer, and academic editor whose support has made us where we are today.

To mark this significant milestone, a Special Issue entitled “10th Anniversary of Biology—Innate Immune System: Insights from Zebrafish Models” is being launched. The innate immune system plays a pivotal role in restoring homeostasis after stress, prominently in the defence against invading pathogens and healing of injured tissues. Cells of the innate immune system recognize and respond to danger signals in order to control infections and prompt tissue repair. Due to its fundamental role, defects in components of the innate immune system leading to insufficient or excessive activation usually result in disease.

In recent decades, the zebrafish has been consolidated as a powerful tool to model human diseases, to explore the mechanisms behind immune-caused diseases, and to dissect the dynamics of pathogenic infections. In fact, zebrafish models have greatly contributed to our knowledge of human infections that are difficult to replicate in mammalian hosts in vivo, as is the case of tuberculosis, which is well modelled in this animal.

This Special Issue aims to bring new research focused on the studies of the innate immune system using zebrafish models, as well as to consolidate and disseminate the state-of-the-art of the field via review articles. We encourage submissions of articles on topics that directly or indirectly affect the zebrafish as a preclinical model for immune diseases, such as tissue damage, inflammation and its resolution, and new tools and advances in genetic and imaging techniques that may translate into new insights on our knowledge of the vertebrate immune system.

Dr. Monica Varela
Dr. Gabriel Forn-Cuní
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • zebrafish
  • innate immunity
  • macrophages
  • neutrophils
  • live imaging
  • development
  • infection
  • tissue repair
  • inflammation

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish
Biology 2023, 12(2), 153; https://doi.org/10.3390/biology12020153 - 19 Jan 2023
Viewed by 583
Abstract
Inflammation is a hallmark of the physiological response to aggressions. It is orchestrated by a plethora of molecules that detect the danger, signal intracellularly, and activate immune mechanisms to fight the threat. Understanding these processes at a level that allows to modulate their [...] Read more.
Inflammation is a hallmark of the physiological response to aggressions. It is orchestrated by a plethora of molecules that detect the danger, signal intracellularly, and activate immune mechanisms to fight the threat. Understanding these processes at a level that allows to modulate their fate in a pathological context strongly relies on in vivo studies, as these can capture the complexity of the whole process and integrate the intricate interplay between the cellular and molecular actors of inflammation. Over the years, zebrafish has proven to be a well-recognized model to study immune responses linked to human physiopathology. We here provide a systematic review of the molecular effectors of inflammation known in this vertebrate and recapitulate their modes of action, as inferred from sterile or infection-based inflammatory models. We present a comprehensive analysis of their sequence, expression, and tissue distribution and summarize the tools that have been developed to study their function. We further highlight how these tools helped gain insights into the mechanisms of immune cell activation, induction, or resolution of inflammation, by uncovering downstream receptors and signaling pathways. These progresses pave the way for more refined models of inflammation, mimicking human diseases and enabling drug development using zebrafish models. Full article
Show Figures

Figure 1

Back to TopTop