Advancements in Mesenchymal Stem Cell-Derived Secretome
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 188
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, mesenchymal stem cell (MSC)-derived secretome, including its subcomponents such as extracellular vesicles, has garnered increasing attention due to its remarkable regenerative and immunomodulatory potential, underscoring its applicability across a wide range of clinical scenarios. Encompassing a diverse repertoire of bioactive molecules—including cytokines, chemokines, growth factors, and microRNAs—the MSC secretome has demonstrated therapeutic efficacy comparable to cell transplantation. Indeed, MSCs primarily exert their beneficial effects through paracrine signaling rather than direct cell engraftment. Consequently, the MSC secretome mirrors the actions of its cells of origin by promoting tissue repair and regeneration, modulating immune responses, and mitigating inflammation. Moreover, compared to cell-based therapies, the secretome-based approach offers advantages such as reduced costs, simplified handling, and easier storage.
This Special Issue will highlight recent advancements in MSC secretome research, focusing on innovative applications, mechanistic insights, and future translational directions. By exploring this rapidly evolving field, we aim to gather scientific evidence that can accelerate the development and facilitate the clinical translation of innovative, cell-free therapeutic strategies.
In this Special Issue, the submission of reviews, perspectives, opinions, and original research articles on topics related to “Advancements in Mesenchymal Stem Cell-Derived Secretome” is welcome. Submissions may investigate the secretome composition and evaluate its efficacy using in vitro, ex vivo, and in vivo experimental models covering diverse medical fields, including but not limited to immunology, orthopedics, maxillofacial medicine, neurology, and cardiology.
Dr. Chiara Giannasi
Guest Editor
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Keywords
- mesenchymal stem cells
- secretome
- extracellular vesicles
- conditioned medium
- cell-free therapeutics
- regeneration
- immunomodulation
- inflammation
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