Special Issue "Extracellular Vesicles from Health to Disease: Positive or Negative Benefits"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 138

Special Issue Editors

Dr. Tommaso Neri
E-Mail Website
Guest Editor
UO Pneumologia, Azienda Ospedaliera Universitaria Pisana, 56126 Pisa, Italy
Interests: extracellular vesicles; mechanism underlying extracellular vesicles generation; intercellular communication; inflammatory markers; miRNAs; inflammation; coagulation; lung diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Dario Nieri
E-Mail Website
Guest Editor
UO Pneumologia, Azienda Ospedaliera Universitaria Pisana, 56126 Pisa, Italy
Interests: extracellular vesicles; chronic obstructive pulmonary disease; lung inflammation; thrombosis, endotypes
Special Issues, Collections and Topics in MDPI journals
Dr. Erica Bazzan
E-Mail Website
Guest Editor
Dipartimento di Scienze Cardio-Toraco-Vascolari e Sanita' Pubblica, Università di Padova, 35128 Padova, Italy
Interests: extracellular vesicles; inflammatory markers; miRNAs; cell inflammation; lung diseases; alveolar macrophages polarization

Special Issue Information

Dear Colleagues,

“Extracellular vesicles (EV)” is a wide term that includes many different types of vesicles, secreted into the extracellular environment by virtually all cell types. Indeed, EVs have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid, where they transport different molecules, including mRNA, microRNA, proteins, and lipids, primarily involved in intercellular communication and fundamental biological pathways, like inflammation or coagulation. Exosomes and microvesicles/ectosomes, collectively termed EV, have recently attracted much interest because of their functions in health and disease, their potential role as biomarkers and possible therapeutic exploitation. Due to its enormous relevance, this relatively new field of research is quickly expanding. For this Special Issue, we invite researchers to contribute with either original research (both in vivo or in vitro studies) or review articles focusing on the potential role of EV in pathophysiological mechanisms and their relevance as diseases biomarkers or as therapeutic tools.

Dr. Tommaso Neri
Dr. Dario Nieri
Dr. Erica Bazzan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • exosomes
  • microparticles
  • EV mechanisms of action
  • biomarkers
  • EV in diseases
  • EV as therapeutic tools

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Asthma

Abstract: Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. Novel reliable noninvasive biomarker useful for the diagnosis of asthma and its clinical phenotypes are urgently needed. The molecular constituents of exosomes, especially exosomal microRNAs (miRNAs), have considerable potential as novel biomarkers for clinical diagnosis. The purpose of this work will be to explore aberrant exosomal miRNA profiles by using small RNA sequencing in in severe asthma patients versus mild to moderate asthma patients. The obtained results will be confirmed with quantitative RT-PCR. It has been shown that exosomal miRNAs could influence several physiological and pathological processes, including those involved in asthma. We want to prove the involvement of exosomal miRNAs in the pathogenesis of asthma in order to demonstrate that exosomal miRNAs profile may be useful for diagnosis and discrimination of clinical phenotypes of asthma.

Title: A BAL Exosomal miRNA Signature in IPF

Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology which leads rapidly to death. As diagnosis of IPF is complex, the current challenge is the identification of early diagnostic and prognostic biomarkers for this debilitating disease. In this study, we will to profile microRNA (miRNA) expression of BAL-derived exosomes in IPF disease by small RNA sequencing. Sequencing of 37 IPF patients and 43 non-IPF subjects will allow to identify differentially expressed exosomal miRNAs. By using quantitative RT-PCR, we will validate the alteration of exosomal miRNAs in the studied cohort. Differentially expressed miRNAs in the BAL-derived exosomes of IPF compared to non-IPF group could help to individuation of promising diagnostic and prognostic biomarkers. Furthermore, these possible findings may open new perspectives for the development of therapeutics.

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