Special Issue "Drosophila, a model to study RNA modification and epitranscriptomics"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Dr. Alessia Soldano
Guest Editor
CIBIO, University of Trento, Italy
Interests: neurodevelopment; genetics; epitranscriptomics; neurodegeneration; brain wiring

Special Issue Information

Dear Colleagues,

RNA is a heavily modified molecule with over 150 modifications described across different species. These modifications can change both the chemical and structural properties of RNA and have effects on many aspects of RNA biology. While the understanding of tRNA and rRNA modifications is relatively broad, that of mRNA is far less so. Despite the presence of many modifications on mRNA,  few have been characterized and the understanding of their contribution to mRNA biology in vivo remains elusive. Recently, it was demonstrated that modifications such as N6-methyladenosine (m6A), N6,2’-O-dimethyladenosine (m6Am), pseudouridine (Ψ), and ribose 2′-O-methylation (Nm) are widespread on mRNA. Other modifications, such as N1-methyladenosine (m1A) and cytosine modifications, like 5-methylcytosine (m5C) and 5-hydroxymethylcytosine (hm5C), also exist, but their relevance and presence is still controversial. Interestingly, some of the RNA modifications are not permanent; they can be removed allowing a fast response to different environmental or cellular conditions. Therefore, these modifications represent a novel level of gene expression regulation, one that led to the development of the “epitranscriptomics” field.

This Special Issue of Biology is focused on the biological functions of mRNA modifications and the molecular mechanisms underlying these functions. In particular, the scope includes the contribution of Drosophila melanogaster, as a genetic model, to the field of epitranscriptomics.

In this Special Issue, entitled “Drosophila: A Model to Study RNA Modification and Epitranscriptomics”, original research and review articles will give the readers an overview of the recent developments in the field.

Dr. Alessia Soldano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Drosophila genetics
  • epitranscriptomics
  • mRNA modifications
  • mRNA biology
  • molecular mechanism
  • mRNA stability
  • mRNA translation

Published Papers

This special issue is now open for submission.
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