Special Issue "Cancer Related Lymphedema"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editors

Dr. Babak J. Mehrara
Guest Editor
Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Interests: Secondary lymphedema; inflammation; fibrosis; T cells; drug development; surgical treatment of lymphedema; pathophysiology of lymphedema
Special Issues and Collections in MDPI journals
Dr. Raghu P. Kataru
Guest Editor
Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Interests: Lymphangiogenesis; inflammatory regulation; immune responses; fibrosis; secondary lymphedema; T cells; lymphatic trafficking
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The last decade has been notable in terms of advances in medical and surgical treatment of secondary lymphedema. This is particularly important since secondary lymphedema is a morbid and life-long disease that affects a large number of patients treated for solid cancers. The advances in medical and surgical treatments of this disease have been made possible by improvements in surgical techniques and key discoveries that have shed light on the pathophysiology of lymphedema. Understanding the mechanisms that regulate lymphatic degeneration following lymphatic injury has led to clinical trials of medical therapies aiming to reverse these pathways. Indeed, preclinical studies have shown the important role of chronic inflammation, changes in lymphatic smooth muscle cells, tissue fibrosis, lymphatic pumping, and regulation of collateral lymphatic channels.

Similarly, surgical therapies such as lymph node transplantation and lymphovenous bypass have been developed to reverse the pathologic changes of lymphedema and show promise in some settings. These studies have highlighted the importance of presurgical lymphatic imaging, development of novel surgical techniques, and unique challenges in quantifying outcomes following surgery.

This Special Issue aims to summarize our current understanding of the pathophysiology of lymphedema and how this knowledge is used in designing novel medical and surgical therapies for this disease.

Dr. Babak J. Mehrara
Dr. Raghu P. Kataru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • secondary lymphedema
  • pathophysiology
  • inflammation
  • lymphangiogenesis
  • lymphatic pumping
  • lymphatic leakiness
  • lymphatic smooth muscle cells
  • fibrosis
  • T cells
  • surgical treatment of lymphedema
  • lymphovenous bypass
  • lymph node transplantation
  • liposuction
  • surgical outcomes of lymphedema

Published Papers

This special issue is now open for submission.
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