Special Issue "Alternative End-Joining Repair Pathway"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: 30 December 2021.

Special Issue Editor

Dr. Lauréline Roger
E-Mail Website
Guest Editor
Muséum National d'Histoire Naturelle, Structure et Instabilité des Génomes, CNRS UMR 7196 / INSERM U1154, 43 rue Cuvier - Case postale 26, 75231 Paris Cedex 05, France
Interests: DNA repair; replication stress; Alt-EJ; telomere

Special Issue Information

Dear colleagues,

The thorough and efficient repair of DNA double strand breaks (DSBs) is crucial to maintain genome integrity. DSBs can occur naturally during DNA replication or following exposure to DNA damaging agents. DSBs are usually repaired by homologous recombination (HR) or non-homologous end joining (NHEJ).

A lesser-known alternative end joining pathway (Alt-EJ) can also be used to repair DSBs. In contrast to HR and C-NHEJ, Alt-EJ is intrinsically mutagenic as it uses microhomologies to align broken ends before joining, which ultimately generates deletions on each side of the original DSB. Alt-EJ was initially described as a back-up pathway for NHEJ or HR. However, studies in several model organisms have shown that Alt-EJ can act as an independent pathway in different contexts even when HR or C-NHEJ are proficient.

Nevertheless, further knowledge is required to better understand the physiological functions of Alt-EJ, to characterize its regulation during the choice of the repair pathway and to identify new genes involved in Alt-EJ. 

For this Special Issue, we invite the submission of short communications, research manuscripts, and review manuscripts, covering all aspects of Alt-EJ biology.

Dr. Lauréline Roger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA double strand break repair
  • Alt-EJ
  • MMEJ
  • Polθ
  • DNA ligase 3
  • PARP1
  • Microhomologies
  • Deletions

Published Papers

This special issue is now open for submission.
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