Novel Dynamics and Mechanisms of Stromal–Leukocyte Interactions in Tissue Inflammation, Immunity and Healing
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 921
Special Issue Editors
Interests: gastrointestinal pathophysiology
Special Issues, Collections and Topics in MDPI journals
Interests: cell-cell communication; post-translational modification; receptor-ligand & TCR-antigenic pMHC interactions
Special Issues, Collections and Topics in MDPI journals
Interests: barrier pathophysiology; cytokines networks
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic inflammatory diseases and tissue healing processes are governed by intricate cellular and molecular interactions between stromal cells and leukocytes. While significant progress has been made in understanding immune cell functions, the role of tissue-resident stromal cells—such as fibroblasts, endothelial cells and mesenchymal cells—in shaping inflammation, immunity and repair remains incompletely elucidated. Emerging technologies, including single-cell multi-omics, spatial transcriptomics and advanced imaging, have unveiled unprecedented insights into these dynamic interactions, revealing novel mechanisms that dictate disease progression, immune regulation and tissue regeneration.
This Special Issue aims to highlight cutting-edge research that explores the bidirectional crosstalk between stromal cells and leukocytes in the context of inflammation, immunity and healing. We invite submissions of original research articles and reviews that delve into the molecular and cellular mechanisms underlying these interactions, with emphasis on:
Novel stromal–immune signaling pathways driving chronic inflammation or resolution; spatiotemporal dynamics of stromal–leukocyte interactions in diseased versus healing tissues; metabolic and epigenetic regulation of stromal–immune crosstalk; and technological innovations (e.g., AI-driven modeling, organ-on-chip systems, live imaging) that advance the study of these interactions.
We look forward to your contributions to this Special Issue.
Dr. Matthias Friedrich
Dr. Pablo Céspedes
Dr. Mathilde Pohin
Guest Editors
Manuscript Submission Information
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Keywords
- stromal–immune crosstalk
- chronic inflammation
- tissue repair and regeneration
- single-cell omics
- immunometabolism
- fibrosis
- spatial transcriptomics
- immune tolerance
- cytokine signaling
- stromal niche immunology
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