Novel Dynamics and Mechanisms of Stromal–Leukocyte Interactions in Tissue Inflammation, Immunity and Healing
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 6
Special Issue Editors
Interests: gastrointestinal pathophysiology
Special Issues, Collections and Topics in MDPI journals
Interests: cell-cell communication; post-translational modification; receptor-ligand & TCR-antigenic pMHC interactions
Special Issues, Collections and Topics in MDPI journals
Interests: barrier pathophysiology; cytokines networks
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic inflammatory diseases and tissue healing processes are governed by intricate cellular and molecular interactions between stromal cells and leukocytes. While significant progress has been made in understanding immune cell functions, the role of tissue-resident stromal cells—such as fibroblasts, endothelial cells and mesenchymal cells—in shaping inflammation, immunity and repair remains incompletely elucidated. Emerging technologies, including single-cell multi-omics, spatial transcriptomics and advanced imaging, have unveiled unprecedented insights into these dynamic interactions, revealing novel mechanisms that dictate disease progression, immune regulation and tissue regeneration.
This Special Issue aims to highlight cutting-edge research that explores the bidirectional crosstalk between stromal cells and leukocytes in the context of inflammation, immunity and healing. We invite submissions of original research articles and reviews that delve into the molecular and cellular mechanisms underlying these interactions, with emphasis on:
Novel stromal–immune signaling pathways driving chronic inflammation or resolution; spatiotemporal dynamics of stromal–leukocyte interactions in diseased versus healing tissues; metabolic and epigenetic regulation of stromal–immune crosstalk; and technological innovations (e.g., AI-driven modeling, organ-on-chip systems, live imaging) that advance the study of these interactions.
We look forward to your contributions to this Special Issue.
Dr. Matthias Friedrich
Dr. Pablo Céspedes
Dr. Mathilde Pohin
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stromal–immune crosstalk
- chronic inflammation
- tissue repair and regeneration
- single-cell omics
- immunometabolism
- fibrosis
- spatial transcriptomics
- immune tolerance
- cytokine signaling
- stromal niche immunology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
