Research on the Interaction Mechanism Between Animal Intestine and Its Microbiota

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 1 July 2026 | Viewed by 954

Special Issue Editors

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: animal nutrition; gut microbiota; gut barrier; immune homeostasis

E-Mail Website
Guest Editor
College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China
Interests: multidrug-resistant bacteria; innate immunity; inflammatory response

Special Issue Information

Dear Colleagues,

The origins and establishment of gut microbiota in early life have a critical relationship with the host and play an important role in animal health and disease. The composition and diversity of the animal’s gut microbiota can be affected by many factors, including dietary components, drug usage, and living environment. The metabolites produced by gut microbiota can regulate the functions of the animal immune system and influence immune and metabolism-related diseases. Previous animal and clinical studies have found that oral administration of probiotics and prebiotic could increase the abundance of beneficial intestinal bacteria and inhibit the growth of harmful intestinal bacteria. The multi-pathway, multi-target, multi-effect integrated regulations on the gut microbiota could improve the animal’s health by maintaining immune homeostasis. Therefore, further study should be applied to explore the mechanism between the animal intestine and its microbiota.

We are pleased to invite you to contribute to our Special Issue on “Research on the Interaction Mechanism Between Animal Intestine and Its Microbiota” in our journal. This Special Issue will collect manuscripts dedicated to the comprehension of the diversity, metabolites, and interaction mechanisms of gut microbiota in animals. Multi-omics (genomics, transcriptomics, proteomics, metabolomics, phenomics, etc.) investigate the interaction mechanism of gut microbiota and the animal intestine at the gene, protein, metabolic, and phenotypic level are welcome.

This Special Issue welcomes submissions of original research and review manuscripts focusing on the interaction mechanism between the animal intestine and its microbiota.

Dr. Zongjie Li
Dr. Xiaomin Guo
Guest Editors

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Keywords

  • animal disease
  • innate immunity
  • gut microbiota
  • gut barrier
  • immune homeostasis

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Published Papers (1 paper)

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Research

16 pages, 4354 KB  
Article
The Gut Microbiome and Metabolome of Domestic Cats Were Altered by the Oral Administration of Complex Probiotics
by Yanfeng Ma, Yuhua Hu, Junjie Zhang, Qing Sun, Hongyan Wang, Xinda Liu, Weipeng Tian, Wenhao Wang, Xuelian Ma, Donghua Shao, Ke Liu, Beibei Li, Yafeng Qiu, Zhiyong Ma, Zongjie Li and Jianchao Wei
Biology 2026, 15(8), 652; https://doi.org/10.3390/biology15080652 - 20 Apr 2026
Viewed by 459
Abstract
Probiotics are commonly applied to maintain the balance of gut microbiota and regulate the intestinal metabolic function of companion animals. In the present study, complex probiotics (Bacillus coagulans SNZ-1969, Bacillus subtilis, and Bacillus licheniformis) were added into the basal diet [...] Read more.
Probiotics are commonly applied to maintain the balance of gut microbiota and regulate the intestinal metabolic function of companion animals. In the present study, complex probiotics (Bacillus coagulans SNZ-1969, Bacillus subtilis, and Bacillus licheniformis) were added into the basal diet of domestic cats to investigate their influence on the intestinal microbiome and metabolic characteristics. Results revealed that the alpha diversity of the gut microbiota in the probiotic group was enhanced when compared to the control group. The beta diversity of the gut microbiota was also altered by the oral consumption of the complex probiotics. Compared to the control group, the relative abundance of beneficial microbes (such as Clostridium, Bacteroides, Phocaeicola, and Ruminococcus) in the probiotic group was enhanced, while the relative abundance of opportunistic pathogens (such as Escherichia, Gallibacter, Corynebacterium) was decreased. Additionally, the intestinal metabolic characteristics of domestic cats were also changed. The metabolomic analysis identified 408 differential metabolites between the two groups, and the KEGG function pathway analysis proved that the dominant pathway related to the differential metabolites were the amino acid metabolism, lipid metabolism, carbohydrate metabolism, energy metabolism, endocrine system, digestive system, immune system, and other metabolic pathways. Spearman’s correlation analysis revealed that the beneficial microbes had positive correlations with the differential metabolites. In conclusion, the current study demonstrated that oral administration of complex probiotics could regulate overall health and well-being in domestic cats through modulating the gut microbiome and metabolic characteristics. Full article
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