Erythrocytes in Human Life—Functions Beyond Oxygen Transport

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: 15 November 2026 | Viewed by 650

Special Issue Editors

Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Interests: immunology; immunochemistry; cell biology; biotechnology

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Guest Editor
Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Interests: red blood cell-based drug delivery systems; extracellular hemoglobin; encapsulation/immobilization technology; liposomes; nutraceuticals

Special Issue Information

Dear Colleagues,

This Special Issue explores the expanding knowledge of erythrocytes, extending beyond their traditional role in oxygen transportation. Using cutting-edge omics technologies, biochemical and biophysical analyses, and advanced microscopy techniques, researchers have unveiled mechanisms of the complex contributions of erythrocytes to immune regulation, redox homeostasis, metabolic control, and intercellular communication. These modern approaches have deepened our understanding of the active, systemic role of erythrocytes in physiological processes (such as aging and exercise, in addition to others) and pathological conditions, including cardiovascular, malignant, infectious, autoimmune, and metabolic diseases, paving the way for novel diagnostic tools and therapeutic strategies. In addition, the unique biological features of erythrocytes—biocompatibility, long circulation lifespan, immune evasion, and the ability to be engineered—position them as promising therapeutic agents.

By integrating basic research and clinical perspectives, this Special Issue aims to provide a comprehensive overview of erythrocyte biology, highlighting their systemic importance in human health and disease, as well as their biomedical applications. We welcome submissions of both original research articles and review papers that focus on experimental data (including those from experimental and domestic animals), methodologies, and theoretical frameworks related to the significance of erythrocytes in human life.

Dr. Vesna Ilic
Dr. Ivana Drvenica
Guest Editors

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Keywords

  • erythrocytes in physiological processes
  • erythrocytes in disease pathophysiology
  • erythrocyte biomechanics
  • erythrocyte imaging
  • erythrocyte membrane
  • erythrocyte metabolism
  • haemoglobin
  • immune modulation
  • redox homeostasis

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Published Papers (1 paper)

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Review

16 pages, 2572 KB  
Review
Deconvolution of Red Blood Cells Thermal Fluid Biopsy Following Systematic Cyclophosphamide or Cilostazol Drug Therapies
by Andrea Ferencz and Dénes Lőrinczy
Biology 2026, 15(10), 792; https://doi.org/10.3390/biology15100792 - 15 May 2026
Viewed by 195
Abstract
Beyond gas transport, red blood cells (RBCs) have emerging roles regarding innate immunity, regulating blood flow, and participating in nutrient transport, which can be engineered as drug delivery systems since they contribute to maintaining water homeostasis. Following extensive thermoanalytical studies of human blood [...] Read more.
Beyond gas transport, red blood cells (RBCs) have emerging roles regarding innate immunity, regulating blood flow, and participating in nutrient transport, which can be engineered as drug delivery systems since they contribute to maintaining water homeostasis. Following extensive thermoanalytical studies of human blood plasma, our working group investigated the properties of RBCs, examining their role in healthy and in different disease states by using differential scanning calorimetry (DSC) and the deconvolution of the resulting thermal curve. In the first study, guinea pigs were treated with intraperitoneal chemotherapy. Cyclophosphamide treatment showed a dose-dependent difference between the thermal parameters of control and treated samples, indicating that DSC can be used in this area. Following deconvolution of the DSC studies, the changes can be attributed to the damaged compounds. In the second part of our study, a method for the thermal analysis and deconvolution of RBCs in patients with lower limb ischemia during a three-month cilostazol treatment was developed. The control DSC curve showed 5–6 distinct thermal domains, and in contrast to other drug treatments, this remained stable throughout the entire study period. No effects of stiffness or compact were caused by the anticancer drug cyclophosphamide were observed in the structure of RBCs. These preliminary results highlight the uniqueness of thermodynamic studies of RBCs and provide a fingerprint-like identification of a given individual or disease state. Full article
(This article belongs to the Special Issue Erythrocytes in Human Life—Functions Beyond Oxygen Transport)
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