Research Advances on Biology and Genetics of Bees

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Zoology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1068

Editors


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Guest Editor
State Key Laboratory of Resource Insects, Key Laboratory of Insect-Pollinator Biology of Ministry of Agriculture and Rural Affairs, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: honey bee; biodiversity; habitat; DNA; microbiota; adaptation; biophysical environment

E-Mail Website
Guest Editor
State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: honey bee; biophysical environment ; gene expression; breeding

Special Issue Information

Dear Colleagues,

Bees—including honey bees (Apis spp.), bumblebees (Bombus spp.), and solitary bees from diverse lineages—are among the most essential pollinators underpinning terrestrial biodiversity and global food security. Through their diverse foraging behaviors, social structures, and ecological interactions, they ensure the reproduction of countless wild and cultivated plants. In the Anthropocene, bees face an unprecedented convergence of environmental stressors—pathogens, parasites, pesticide exposure, habitat degradation, nutritional scarcity, and climatic instability—that collectively endanger their population viability, colony performance, and pollination function.

These multifaceted challenges not only threaten bee species individually but also disrupt the intricate pollination networks upon which ecosystem stability and agricultural productivity depend. Understanding how different bee taxa respond and adapt to these pressures is fundamental for developing effective conservation and management strategies.

This Special Issue aims to provide an integrative platform for research on the biology, genetics, and ecology of bees as pollinators. We invite contributions that explore the molecular and physiological mechanisms underlying bee adaptation, stress resistance, and reproductive success, as well as studies investigating the evolutionary and behavioral foundations of foraging and social organization. Particular attention is given to the use of advanced omics technologies (genomics, transcriptomics, proteomics, metabolomics, epigenomics) to uncover the genetic and regulatory bases of key traits related to bee health, nutrition, communication, and resilience. These contributions present bring tools and approaches for bee breeding, disease control, habitat restoration, and pollinator-friendly agricultural practices. By integrating insights across species and disciplines, this Special Issue seeks to deepen our understanding of how honey bees, bumblebees, and solitary bees sustain their ecological roles under accelerating global change, and how research can help secure their future and the vital pollination services they provide.

Dr. Jiaxing Huang
Dr. Guiling Ding
Guest Editors

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Keywords

  • bee biology
  • pollination ecology
  • environmental stressors
  • bee genomics and omics
  • bee health and conservation
  • foraging behavior and social organization

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Published Papers (1 paper)

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Research

22 pages, 4632 KB  
Article
Metabolic Landscape and Cell-Type-Specific Transcriptional Signatures Associated with Dopamine Receptor Activation in the Honeybee Brain
by Miaoran Zhang, Kai Xu, Meng Xu, Jieluan Li, Yijia Xu, Qingsheng Niu, Xingan Li and Peng Chen
Biology 2026, 15(2), 174; https://doi.org/10.3390/biology15020174 - 17 Jan 2026
Viewed by 804
Abstract
Background: Honeybees sustain vital ecological roles through foraging behavior, which provides pollination services and is likely regulated by dopamine signaling coupled to brain energy metabolism. However, the genetic and metabolic mechanisms underlying this regulation remain unclear. Methods: We treated honeybee workers with the [...] Read more.
Background: Honeybees sustain vital ecological roles through foraging behavior, which provides pollination services and is likely regulated by dopamine signaling coupled to brain energy metabolism. However, the genetic and metabolic mechanisms underlying this regulation remain unclear. Methods: We treated honeybee workers with the dopamine receptor agonist bromocriptine and employed an integrative approach, combining liquid chromatography–mass spectrometry (LC–MS) metabolomics with single-nucleus RNA sequencing (snRNA-seq). Results: Metabolomics revealed increased levels of N6-carboxymethyllysine (CML) and a coordinated shift in central carbon metabolites, including higher glucose, pyruvate, and lactate within glycolysis, and ribose-5-phosphate in the pentose phosphate pathway (PPP). Integration with transcriptomics showed heterogeneous responses: glial cells exhibited higher glycolysis pathway scores and upregulated hexokinase expression compared to neurons, whereas major PPP enzymes were upregulated in both glial and neuronal subsets. Conclusions: These findings suggest that dopamine receptor activation is associated with altered whole-brain metabolic profiles and concurrent, cell-type-specific upregulation of glycolytic and PPP enzyme genes, particularly in glia. This study characterizes these neuro-metabolic associations, offering insights into the cellular and metabolic basis of foraging behavior in worker bees. Full article
(This article belongs to the Special Issue Research Advances on Biology and Genetics of Bees)
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