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Biology
Special Issues
15 Years of Biology: The View Ahead
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15 Years of Biology: The View Ahead

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1296

Special Issue Editor

Prof. Dr. Andrés Moya

E-Mail Website
Guest Editor
Integrative Systems Biology Institute, University of Valencia and CSIC, 46980 Valencia, Spain
Interests: genetics; biological evolution; experimental and genome evolution; philosophy of biology; study of the human and animal microbiome under an evolutionary and system biology perspective
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue celebrates the 15th anniversary of Biology and marks Biology’s strategic shift from general coverage to theoretical integration in life sciences, anchored by the Editorial “Biology: The Open Road to a Theory of Life”. Centered on developing a “theory of cellular life,” the new development promotes cross-scale, biocomputing-driven research that transcends traditional biological boundaries. In recognition of this milestone, we particularly encourage submissions from our Editorial Board Members leveraging their expertise in peer review standards and the journal’s new direction to lead this theoretical transformation.

Prof. Dr. Andrés Moya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • behavioral biology
  • bioinformatics
  • biophysics
  • biotechnology
  • cancer biology
  • cell biology
  • conservation biology and biodiversity
  • developmental and reproductive biology
  • ecology
  • evolutionary biology
  • genetics and genomics
  • immunology
  • infection biology
  • marine and freshwater biology
  • medical biology
  • microbiology
  • neuroscience
  • physiology
  • plant science
  • toxicology
  • theoretical biology and biomathematics
  • zoology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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15 pages, 938 KB  
Article
Sperm Antioxidant Capacity Discriminates Between Fertile and Infertile Men and Is Strictly Related to Lipid Peroxidation and Lipid Mediator Production
by Cinzia Signorini, Elena Moretti, Laura Liguori, Elena Leoni, Caterina Marcucci, Maria Cristina Salvatici and Giulia Collodel
Biology 2026, 15(10), 760; https://doi.org/10.3390/biology15100760 - 10 May 2026
Viewed by 433
Abstract
Oxidative stress (OS) and inflammation are common causes of male infertility; antioxidants in spermatozoa and especially in seminal plasma play a protective role. The study aims to evaluate whether OS lipid mediators (F2-isoprostanes: F2-IsoPs; Resolvin D1: RvD1) measured in [...] Read more.
Oxidative stress (OS) and inflammation are common causes of male infertility; antioxidants in spermatozoa and especially in seminal plasma play a protective role. The study aims to evaluate whether OS lipid mediators (F2-isoprostanes: F2-IsoPs; Resolvin D1: RvD1) measured in seminal plasma, and Trolox equivalent antioxidant capacity (TEAC), measured in both seminal plasma and spermatozoa, are associated with male infertility. Semen samples (18 fertile and 62 infertile subjects) were examined following WHO guidelines and with a mathematically elaborated transmission electron microscopy analysis (fertility index-FI-, % sperm pathologies). F2-Isops were measured by GC/NICI-MS/MS, RvD1 by ELISA, and TEAC by a commercially available antioxidant assay. F2-Isops, RvD1, and sperm TEAC (positively interrelated with each other) correlated negatively with seminal parameters and FI and positively with sperm pathologies. F2-Isops, RvD1, and sperm TEAC levels were significantly higher in infertile vs fertile subjects (p < 0.001). ROC curve analysis demonstrated that sperm TEAC (J index: 0.13 mM) and seminal RvD1 (J index: 38.26 pg/mL) discriminated between fertile and infertile subjects. Spermatozoa stimulate antioxidant capacity in the presence of an OS environment; this data suggests an association in which antioxidant defences may vary in relation to the surrounding seminal plasma. Moreover, sperm TEAC, and to a lesser extent seminal RvD1, emerge as potential markers for identifying infertile patients. Full article
(This article belongs to the Special Issue 15 Years of Biology: The View Ahead)
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Review

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25 pages, 3758 KB  
Review
The Biological Actions and Regulations of Lactic Acid-Linked Histone Lactylation
by Yanli Zhu, Kaiqi Li, Yiting Wang, Yueyao Li, Chuyang Zhu, Cuipeng Zhu, Long Yuan, Ping Hu, Haoyu Liu and Demin Cai
Biology 2026, 15(10), 774; https://doi.org/10.3390/biology15100774 - 13 May 2026
Viewed by 275
Abstract
Once written off as nothing more than a waste product of glycolysis, lactic acid is now seen as a key signaling molecule that operates across a wide range of physiological and pathological processes, from immune regulation and tumor metabolism to neural function. But [...] Read more.
Once written off as nothing more than a waste product of glycolysis, lactic acid is now seen as a key signaling molecule that operates across a wide range of physiological and pathological processes, from immune regulation and tumor metabolism to neural function. But its role goes beyond energy metabolism and cell signaling. Recent studies have uncovered a new type of post-translational modification called histone lactylation, in which lactate itself provides the lactoyl group attached to lysine residues on histones. This modification directly ties a cell’s metabolic state to the epigenetic control of gene expression. For example, histone lactylation helps shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype by fine-tuning gene transcription. In this review, we walk through the discovery and biochemical foundation of histone lactylation; discuss the likely writer and eraser enzymes that manage its dynamic changes; and highlight recent advances in understanding the role of this modification in inflammation, tumorigenesis, neurological disorders, and interactions with gut microbes. We also lay out key unanswered questions and consider why targeting protein lactylation might open up new therapeutic possibilities. Full article
(This article belongs to the Special Issue 15 Years of Biology: The View Ahead)
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