Special Issue "Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 83

Special Issue Editors

Dr. Enrico Berrino
E-Mail Website
Guest Editor
Department of Medical Sciences, Università degli studi di Torino, Torino, Italy
Interests: genetics; genomics; cancer; breast carcinoma; DNAseq; RNAseq
Dr. Sara Erika Bellomo
E-Mail Website
Guest Editor
Department of Oncology, Università degli studi di Torino, Torino, Italy
Interests: genetics; genomics; cancer; bioinfomatics; DNAseq; RNAseq

Special Issue Information

Dear Colleagues,

Retrotransposons represent a huge section of the human genome, and, in particular, the long interspersed nuclear elements-1 (LINE-1) sequences are the most prevalent. Since these elements are usually silenced through DNA methylation in adult tissues, their role is still controverted. However, LINE-1 reactivation has been reported in several human diseases, such as autoimmune syndrome, neurodegenerative pathologies, and cancer. Moreover, recent discoveries suggested feedback between immune modulation and LINE-1 expression.

This Special Issue is devoted to all aspects of LINE-1 reactivation, focusing, in particular, on the following main topics: LINE-1 sequences as biomarkers and their roles in different diseases; the cross-link between LINE-1 and therapeutics related to these diseases; the relationship between LINE-1 and genetics/genomics; and the implementation of the role of LINE-1 in the immune system. Manuscripts are welcome from both preclinical and clinical projects, and, if interesting, also on topics outside of human beings.

Dr. Enrico Berrino
Dr. Sara Erika Bellomo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • LINE-1
  • retrotransposons
  • methylation
  • biomarker
  • immune system
  • genetics

Published Papers

This special issue is now open for submission.
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