Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1574
Special Issue Editors
Interests: genetics; genomics; cancer; breast carcinoma; DNAseq; RNAseq
Special Issue Information
Dear Colleagues,
Retrotransposons represent a huge section of the human genome, and, in particular, the long interspersed nuclear elements-1 (LINE-1) sequences are the most prevalent. Since these elements are usually silenced through DNA methylation in adult tissues, their role is still controverted. However, LINE-1 reactivation has been reported in several human diseases, such as autoimmune syndrome, neurodegenerative pathologies, and cancer. Moreover, recent discoveries suggested feedback between immune modulation and LINE-1 expression.
This Special Issue is devoted to all aspects of LINE-1 reactivation, focusing, in particular, on the following main topics: LINE-1 sequences as biomarkers and their roles in different diseases; the cross-link between LINE-1 and therapeutics related to these diseases; the relationship between LINE-1 and genetics/genomics; and the implementation of the role of LINE-1 in the immune system. Manuscripts are welcome from both preclinical and clinical projects, and, if interesting, also on topics outside of human beings.
Dr. Enrico Berrino
Dr. Sara Erika Bellomo
Guest Editors
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Keywords
- LINE-1
- retrotransposons
- methylation
- biomarker
- immune system
- genetics
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