Bioengineering in Human Induced Pluripotent Stem Cells (iPSCs)
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 14799
Special Issue Editor
Special Issue Information
Dear Colleagues,
When combined with bioengineering approaches, human pluripotent stem cells hold great promise for a number of biomedical applications. Most of these applications fall into one of two general categories: cell-based modeling systems or regenerative medicine. In this Special Issue on “Bioengineering in Human Induced Pluripotent Stem Cells”, contributions tackling the many bioengineering challenges that are crucial for creating successful modeling systems and regenerative medicine approaches utilizing human-induced pluripotent stem cells (iPSCs) or human embryonic stem cells (hESCs) will be showcased.
Such modeling systems have helped further our understanding of healthy and disease states and supported improved drug testing platforms. More accurate modeling systems and high-throughput drug screening platforms have been developed by combining pluripotent stem cells with bioengineered cell culture approaches (biomimetic 3D culture systems, incorporating extracellular matrix (ECM) proteins, bioprinting, automation, etc.). These advancements, together with the ability to use human iPSCs in a patient-specific manner, have helped support a shift from personalized medicine to patient-specific therapies. However, challenges remain in the reproducibility, streamlining, and scale-up to make patient-specific therapies a viable option for most patients.
Considerable progress has been made in the field of regenerative medicine, which has focused on using iPSCs or hESCs clinically for repairing or replacing damaged cells or tissues. Key hurdles include developing scaffolds and other systems suitable for transplantation, clinical scale-up, shifting from 2D to 3D culture systems, and manufacturing demands. Most recently, the cells themselves are being bioengineered using genome editing techniques (e.g., CRISPR/Cas9) to enhance cellular performance.
Original research articles and reviews are welcome in all relevant areas of research.
Dr. Teisha J. Rowland
Guest Editor
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Keywords
- human induced pluripotent stem cells (iPSCs)
- human embryonic stem cells (hESCs)
- regenerative medicine
- organoids
- organ-on-a-chip
- bioreactor culture systems
- tissue bioengineering
- biomaterials
- biomimetic
- extracellular matrix (ECM)
- disease modeling
- drug discovery
- drug testing
- gene editing
- patient-specific therapies
- clinical translation
- transplantations
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