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Bioengineering
Special Issues
Microfluidics and Sensor Technology in Biomedical Engineering
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Microfluidics and Sensor Technology in Biomedical Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biofabrication and Biomanufacturing".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 2886

Special Issue Editors

Dr. Bharath Babu Nunna

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Weber State University, Ogden, UT 84408, USA
Interests: microfluidics; electrochemical sensing technologies; micro/nano fabrication; lab-on-the-chip; point-of-care-technologies
Special Issues, Collections and Topics in MDPI journals
Dr. Eon Soo Lee

E-Mail Website
Guest Editor
Mechanical and Industrial Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, USA
Interests: biomedical microdevices; microfluidics; graphene/CNT; electrochemical system; battery/fuel cell
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics and sensing technologies are key fundamental elements for biomedical engineering advancements, especially in the development of miniaturized disease diagnostic/monitoring devices. The recent pandemic has furthered the need for the rapid and dynamic evolution of advanced biomedical technologies. The innovative developments made in microfluidic and sensing technologies play a significant role in dynamically evolving biomedical engineering applications, especially in Lab-on-the-Chip, Organ-on-the-Chip and Point-of-Care technologies, among others. The rapidly emerging fabrication techniques in MEMS and NEMS have opened the doors to new sensing technologies with high accuracy. The fascinating microfluidic platforms with the latest 2D and 3D structures may have the ability to precisely define the fluid flow patterns and fluid particle transportation in microchannels with desired accuracy. The synergistic integration of microfluidic and sensing technologies has paved the way for many recent innovations in biomedical engineering, thus contributing to the development of sophisticated equipment for improving human health. This Special Issue will cover the recent and innovative advances made in the development of microfluidic platforms, smart micro/nano-biomedical devices, the integration of MEMS/NEMS, and technical and translational challenges, along with a broader impact. Contributions may address, for example:

  • Advancements in the fabrication of 2D and 3D microfluidic and sensing platforms.
  • The synergistic integration of microfluidic and sensing technologies.
  • Novel micro/nano-biomedical device design and development with microfluidic platforms.
  • The integration of artificial intelligence to control micro/nano biomedical devices.

Dr. Bharath Babu Nunna
Dr. Eon Soo Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

17 pages, 14873 KiB  
Article
Features of Vat-Photopolymerized Masters for Microfluidic Device Manufacturing
by Maria Laura Gatto, Paolo Mengucci, Monica Mattioli-Belmonte, Daniel Munteanu, Roberto Nasini, Emanuele Tognoli, Lucia Denti and Andrea Gatto
Bioengineering 2024, 11(1), 80; https://doi.org/10.3390/bioengineering11010080 - 15 Jan 2024
Cited by 1 | Viewed by 883
Abstract
The growing interest in advancing microfluidic devices for manipulating fluids within micrometer-scale channels has prompted a shift in manufacturing practices, moving from single-component production to medium-size batches. This transition arises due to the impracticality of lab-scale manufacturing methods in accommodating the increased demand. [...] Read more.
The growing interest in advancing microfluidic devices for manipulating fluids within micrometer-scale channels has prompted a shift in manufacturing practices, moving from single-component production to medium-size batches. This transition arises due to the impracticality of lab-scale manufacturing methods in accommodating the increased demand. This experimental study focuses on the design of master benchmarks 1–5, taking into consideration critical parameters such as rib width, height, and the relative width-to-height ratio. Notably, benchmarks 4 and 5 featured ribs that were strategically connected to the inlet, outlet, and reaction chamber of the master, enhancing their utility for subsequent replica production. Vat photopolymerization was employed for the fabrication of benchmarks 1–5, while replicas of benchmarks 4 and 5 were generated through polydimethylsiloxane casting. Dimensional investigations of the ribs and channels in both the master benchmarks and replicas were conducted using an optical technique validated through readability analysis based on the Michelson global contrast index. The primary goal was to evaluate the potential applicability of vat photopolymerization technology for efficiently producing microfluidic devices through a streamlined production process. Results indicate that the combination of vat photopolymerization followed by replication is well suited for achieving a minimum rib size of 25 µm in width and an aspect ratio of 1:12 for the master benchmark. Full article
(This article belongs to the Special Issue Microfluidics and Sensor Technology in Biomedical Engineering)
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15 pages, 3662 KiB  
Article
Surface Modification of Cyclic-Olefin-Copolymer (COC)-Based Microchannels for the Large-Scale Industrial Production of Droplet Microfluidic Devices
by Yefeng Guan, Huiru Zhang, Zhibin Yan, Xue Wei, Zhuo Zhang and Xuelian Chen
Bioengineering 2023, 10(7), 763; https://doi.org/10.3390/bioengineering10070763 - 25 Jun 2023
Viewed by 1641
Abstract
The copolymers of cycloolefin (COC), a type of thermoplastic material, have been widely used for the large-scale industrial fabrication of droplet microfluidic devices, which is often performed using hot-embossing or injection-molding techniques. The generation of droplets and the uniformity of droplet sizes are [...] Read more.
The copolymers of cycloolefin (COC), a type of thermoplastic material, have been widely used for the large-scale industrial fabrication of droplet microfluidic devices, which is often performed using hot-embossing or injection-molding techniques. The generation of droplets and the uniformity of droplet sizes are significantly affected by the surface wettability of COC during fabrication and the pressure stability of the employed fluid pump during operation. In order to alleviate the effects of undesirable surface wettability and pressure variation on the generation of droplets in COC-based devices, a simple surface modification procedure was applied to hydrophobically modify the surfaces of COC-based microchannels for large-scale industrial production. The surface modification procedure consisted of an oxygen plasma treatment of the polymer surface followed by a solution-phase reaction in fluorocarbon solvent. The experimental results demonstrate that following the proposed surface modification, the COC droplet microfluidic devices could stably generate microvolume water droplets with a small coefficient of variation, even if the pressure of the dispersed phase (water) fluctuated. The durability test results regarding the modified surfaces show that the hydrophobicity of the modified COC surfaces could be sustained for up to four months, deteriorating with time thereafter. Our study can provide a potential solution useful in and guidance for the large-scale industrial production of droplet microfluidic devices for various applications, including polymerase chain reaction and single-cell analysis. Full article
(This article belongs to the Special Issue Microfluidics and Sensor Technology in Biomedical Engineering)
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