Interventional Radiology and Vascular Medicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 2713

Special Issue Editors


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Guest Editor
Department of Radiology, Section of Vascular and Interventional Radiology, Baylor College of Medicine, Houston, TX, USA
Interests: radiology, vascular and interventional radiology

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Guest Editor
Department of Radiology, Division of Vascular and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Interests: medical devices; precision medicine; artificial intelligence

Special Issue Information

Dear Colleagues,

Vascular and Interventional Radiology (VIR) is an evolving discipline at the nexus of bioengineering, clinical medicine, and innovative radiological interventions. This Special Issue of our esteemed Bioengineering journal aims to present groundbreaking developments and contemporary challenges within the world of VIR.

Key Focus Areas:

  1. Personalized Endovascular Devices:
    • The development of bioengineered stents, grafts, or balloons tailored to individual patients using biocompatible materials;
    • The potential to leverage 3D printing technologies to create patient-specific devices.
  2. Smart Catheters:
    • Catheters equipped with sensors to detect physiological changes or to provide real-time feedback during interventional procedures;
    • Integration of AI or machine learning to interpret sensor data and assist radiologists in decision-making.
  3. Imaging Enhancement and Augmented Reality:
    • Research into advanced imaging modalities or contrast agents that can provide clearer, more detailed views of vascular structures;
    • Implementing augmented reality to overlay imaging data during procedures for better guidance;
    • Nanotechnology in Vascular Treatment;
    • Using nanoparticles for targeted drug delivery, specifically during interventional procedures;
    • Nanoparticles that can assist in imaging by enhancing contrast or allowing for molecular-level imaging.
  4. Bioresorbable Vascular Scaffolds:
    • Bioengineered solutions that temporarily provide structural support and then become absorbed by the body, reducing long-term complications like in-stent restenosis;
    • Robotics in Interventional Radiology;
    • Robotic systems to assist or enhance precision in endovascular procedures;
    • The integration of haptic feedback mechanisms to provide tactile information to interventional radiologists.
  5. Biological Interventions:
    • Gene therapy or cell-based therapies for vascular diseases that can be delivered using interventional radiology techniques;
    • Bioengineered solutions to promote vessel healing or reduce inflammation post-intervention.
  6. Wearable Monitors and Post-Procedure Care:
    • Wearables that can monitor vascular health or detect complications early after an interventional procedure;
    • Systems that integrate data from wearables into medical records or alert systems for timely interventions.
  7. Simulation and Training:
    • Development of bioengineered models or virtual reality systems for training in interventional radiology procedures;
    • Simulations that incorporate realistic tissue behavior or patient-specific data for personalized training scenarios.
  8. Patient-Specific Computational Modeling:
    • Leveraging computational tools to model blood flow, vessel behavior, or device interactions specific to individual patients;
    • Using these models to predict the best intervention strategies or potential complications.

This special issue promises to be a treasure trove of knowledge, offering readers a panoramic view of the dynamic world of Vascular and Interventional Radiology. We hope to foster collaborative efforts, spark innovative ideas, and advance the field for better patient care globally.

Dr. Mohammad Ghasemi Rad
Dr. Daye Dania
Guest Editors

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Keywords

  • vascular and interventional radiology
  • bioengineering
  • smart catheters
  • smart stents
  • personalized endovascular devices
  • machine-guided biopsy and ablations

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Published Papers (2 papers)

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Research

15 pages, 5480 KiB  
Article
Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions
by Pablo Jeken-Rico, Yves Chau, Aurèle Goetz, Jacques Sedat and Elie Hachem
Bioengineering 2025, 12(3), 305; https://doi.org/10.3390/bioengineering12030305 - 18 Mar 2025
Viewed by 190
Abstract
Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture. [...] Read more.
Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture. The underlying mechanisms of these ruptures remain unknown, due to the biomechanical complexity of giant aneurysms and challenges in replicating in vivo hemodynamic conditions within numerical simulation frameworks. This study presents a novel fluid–structure interaction simulation of a giant intracranial aneurysm treated with a flow diverter, based on high-resolution rotational angiography imaging. The resulting hemodynamics are compared to three established delayed-rupture hypotheses involving pressure rises, chaotic flow and autolysis. When considering wall compliance, the analysis reveals a consistent phase shift, dampening in pressure cycles, and an increased aneurysmal flow. These findings highlight the need for revisiting existing hypotheses and provide a foundation for advancing both computational modelling and clinical management strategies for giant intracranial aneurysms. Full article
(This article belongs to the Special Issue Interventional Radiology and Vascular Medicine)
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20 pages, 7520 KiB  
Article
Endovascular Treatment of Intracranial Aneurysm: The Importance of the Rheological Model in Blood Flow Simulations
by Maria Antonietta Boniforti, Giorgia Vittucci and Roberto Magini
Bioengineering 2024, 11(6), 522; https://doi.org/10.3390/bioengineering11060522 - 21 May 2024
Cited by 1 | Viewed by 1605
Abstract
Hemodynamics in intracranial aneurysm strongly depends on the non-Newtonian blood behavior due to the large number of suspended cells and the ability of red blood cells to deform and aggregate. However, most numerical investigations on intracranial hemodynamics adopt the Newtonian hypothesis to model [...] Read more.
Hemodynamics in intracranial aneurysm strongly depends on the non-Newtonian blood behavior due to the large number of suspended cells and the ability of red blood cells to deform and aggregate. However, most numerical investigations on intracranial hemodynamics adopt the Newtonian hypothesis to model blood flow and predict aneurysm occlusion. The aim of this study was to analyze the effect of the blood rheological model on the hemodynamics of intracranial aneurysms in the presence or absence of endovascular treatment. A numerical investigation was performed under pulsatile flow conditions in a patient-specific aneurysm with and without the insertion of an appropriately reconstructed flow diverter stent (FDS). The numerical simulations were performed using Newtonian and non-Newtonian assumptions for blood rheology. In all cases, FDS placement reduced the intra-aneurysmal velocity and increased the relative residence time (RRT) on the aneurysmal wall, indicating progressive thrombus formation and aneurysm occlusion. However, the Newtonian model largely overestimated RRT values and consequent aneurysm healing with respect to the non-Newtonian models. Due to the non-Newtonian blood properties and the large discrepancy between Newtonian and non-Newtonian simulations, the Newtonian hypothesis should not be used in the study of the hemodynamics of intracranial aneurysm, especially in the presence of endovascular treatment. Full article
(This article belongs to the Special Issue Interventional Radiology and Vascular Medicine)
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