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Bioengineering
Volume 12
Issue 3
10.3390/bioengineering12030305
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Article

Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions

by
Pablo Jeken-Rico
1,*,
Yves Chau
2,
Aurèle Goetz
1,
Jacques Sedat
2 and
Elie Hachem
1
1
Mines Paris, Université PSL, Centre de Mise en Forme des Matériaux (CEMEF), UMR7635 CNRS, 06904 Sophia Antipolis, France
2
Interventional Neuroradiology Department, Nice University Hospital, 06100 Nice, France
*
Author to whom correspondence should be addressed.
Bioengineering 2025, 12(3), 305; https://doi.org/10.3390/bioengineering12030305
Submission received: 25 February 2025 / Revised: 9 March 2025 / Accepted: 13 March 2025 / Published: 18 March 2025
(This article belongs to the Special Issue Interventional Radiology and Vascular Medicine)
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Abstract

Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture. The underlying mechanisms of these ruptures remain unknown, due to the biomechanical complexity of giant aneurysms and challenges in replicating in vivo hemodynamic conditions within numerical simulation frameworks. This study presents a novel fluid–structure interaction simulation of a giant intracranial aneurysm treated with a flow diverter, based on high-resolution rotational angiography imaging. The resulting hemodynamics are compared to three established delayed-rupture hypotheses involving pressure rises, chaotic flow and autolysis. When considering wall compliance, the analysis reveals a consistent phase shift, dampening in pressure cycles, and an increased aneurysmal flow. These findings highlight the need for revisiting existing hypotheses and provide a foundation for advancing both computational modelling and clinical management strategies for giant intracranial aneurysms.
Keywords: intracranial aneurysms; fluid–structure interaction; delayed rupture; flow diverter intracranial aneurysms; fluid–structure interaction; delayed rupture; flow diverter

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MDPI and ACS Style

Jeken-Rico, P.; Chau, Y.; Goetz, A.; Sedat, J.; Hachem, E. Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions. Bioengineering 2025, 12, 305. https://doi.org/10.3390/bioengineering12030305

AMA Style

Jeken-Rico P, Chau Y, Goetz A, Sedat J, Hachem E. Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions. Bioengineering. 2025; 12(3):305. https://doi.org/10.3390/bioengineering12030305

Chicago/Turabian Style

Jeken-Rico, Pablo, Yves Chau, Aurèle Goetz, Jacques Sedat, and Elie Hachem. 2025. "Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions" Bioengineering 12, no. 3: 305. https://doi.org/10.3390/bioengineering12030305

APA Style

Jeken-Rico, P., Chau, Y., Goetz, A., Sedat, J., & Hachem, E. (2025). Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions. Bioengineering, 12(3), 305. https://doi.org/10.3390/bioengineering12030305

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