DNA-Based Biomaterials: Development and Application
A Special Issue of Bioengineering (ISSN 2306-5354) belonging to the section "Biomedical Engineering and Biomaterials".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 23
Editor
Interests: bionic interface intelligent delivery system/device; organoid personalized therapy; development and research of macro-quantitative DNA biomaterials; immunobiochemical agents
Special Issue Information
Dear Colleagues,
The rational design of advanced biomaterials with tunable physicochemical and biological properties constitutes a fundamental pursuit in biomedical engineering. DNA, long regarded solely as the repository of genetic information, has now been re‑envisioned as a versatile and programmable structural element for constructing functional biomaterials. Leveraging its intrinsic biocompatibility, the fidelity of Watson–Crick base pairing, and sequence programmability, DNA can be assembled into a broad spectrum of well‑defined architectures, including hydrogels, framework nucleic acids, origami nanostructures, and hybrid composite systems, all with precisely controllable geometry, dimensional scale, and biointerfacial functionality. These distinctive capabilities position DNA biomaterials as a transformative platform across diverse application domains, encompassing regenerative medicine, targeted drug delivery, biosensing and bioimaging, immunomodulation, and precision nanomedicine. This Special Issue is devoted to presenting a comprehensive and forward‑looking overview of the latest advances in DNA biomaterial development and their translational applications. We welcome original research articles, comprehensive reviews, methods, mini-reviews, and perspectives, including (but not limited to) the following topics:
- Design, synthesis, and characterization of DNA biomaterials;
- Computational modeling and machine learning approaches for the rational design and optimization of DNA biomaterials;
- Integration of DNA biomaterials with 3D bioprinting, organoid engineering, and advanced live‑cell imaging modalities;
- DNA‑based platforms for controlled drug delivery, gene therapy, biosensing, and bioimaging applications;
- DNA scaffolds and hydrogels for tissue engineering and regenerative medicine;
- DNA nanostructures for immunotherapy, vaccine development, and immunomodulation;
- Strategies and challenges in the clinical translation of DNA biomaterials.
Dr. Jinpeng Han
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA materials
- framework nucleic acids
- DNA origami
- DNA hydrogels
- biomedical engineering
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