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Bioengineering
Special Issues
Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering
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Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2758

Special Issue Editors

Dr. Ali R. Djalilian

E-Mail Website
Guest Editor
Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: bioengineering; ocular surface; stem cells
Special Issues, Collections and Topics in MDPI journals
Dr. Zohreh Arabpour

E-Mail Website
Guest Editor
Department of Ophthalmology and Visual Science, University of Illinois, Chicago, IL 60612, USA
Interests: tissue engineering; regenerative medicine; cell therapy; corneal regeneration; 3D bioprinting

Special Issue Information

Dear Colleagues,

Tissue engineering is entering a new era, one defined by precision, personalization, and the seamless integration of technology and biology. From smart biomaterials that respond to their environment to bioprinted tissues designed for specific patients, the boundaries of what we can create are rapidly expanding.

This Special Issue, “Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering,” brings together the latest advances shaping this exciting frontier. We welcome contributions from researchers and clinicians who are exploring how advanced materials, biofabrication tools, and regenerative techniques can work together to create tissues that truly mimic or even surpass nature.

We invite original research articles, reviews, and short communications that highlight the innovative ideas and technologies driving precision tissue engineering. Topics of interest include, but are not limited to, the following:

- Smart and responsive biomaterials with tunable biological or mechanical properties;

- 3D and 4D bioprinting approaches to create complex and functional tissues;

- Bioactive scaffolds and hydrogels that guide cell behavior and regeneration;

- Stem cell-based and acellular regenerative strategies;

- Computational and AI-based design for personalized biomaterial systems;

- In situ tissue regeneration and smart implant technologies;

- Translational and clinical studies that advance next-generation biomaterials.

Through this Special Issue, we aim to highlight groundbreaking work that not only pushes scientific boundaries but also brings us closer to real-world applications that improve human health and quality of life.

Dr. Ali R. Djalilian
Dr. Zohreh Arabpour
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • tissue engineering
  • regenerative medicine
  • cell therapy
  • 3D/4D printing
  • biofabrication

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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16 pages, 1403 KB  
Article
Chronic In Vivo Biostability and Biocompatibility Evaluation of Polyether-Urethane-Based Balloon Implants for Cardiac Application in a Porcine Model
by Min-Gi Kim, Jae-Young Seo, June-hong Kim, Jin-Chang Kim, Jun-Yong Park, Hyun-A Song, Kyeong-Deok Song and Min-Ku Chon
Bioengineering 2026, 13(2), 168; https://doi.org/10.3390/bioengineering13020168 - 29 Jan 2026
Viewed by 743
Abstract
Polyurethane-based implantable devices (PUIDs) delivered via catheter are increasingly used in structural heart interventions; however, limited in vivo data exist regarding their long-term biostability and biological safety. This study evaluated a balloon-shaped implant made of Pellethane®, a polyether-based polyurethane, designed as [...] Read more.
Polyurethane-based implantable devices (PUIDs) delivered via catheter are increasingly used in structural heart interventions; however, limited in vivo data exist regarding their long-term biostability and biological safety. This study evaluated a balloon-shaped implant made of Pellethane®, a polyether-based polyurethane, designed as a three-dimensional intracardiac spacer and deployed via percutaneous femoral vein access. The device was chronically positioned adjacent to the tricuspid valve annulus in seven pigs for 24 weeks. Explanted devices and surrounding tissues were evaluated through material characterization (SEM, GPC, FT-IR, and 1H-NMR) and histological analysis. SEM and FT-IR confirmed preserved surface morphology and chemical bonds, GPC showed stable molecular weight, and 1H-NMR revealed intact urethane and ether linkages. Materials characterization revealed no evidence of hydrolytic or oxidative degradation, indicating structural stability of the devices. Histological analysis showed stable device positioning with minimal thrombosis or inflammatory response. Biocompatibility was confirmed via ISO 10993-1:2018 Standard (International Organization for Standardization (ISO): Geneva, Switzerland, 2018), and extractable substances were evaluated under exhaustive extraction conditions specified by ISO 10993-18:2020 (International Organization for Standardization (ISO): Geneva, Switzerland, 2020), with no toxicologically significant findings. These findings support the long-term biostability and biological safety of the PUIDs in dynamic cardiac environments, informing future design criteria for catheter-delivered cardiovascular devices. Full article
(This article belongs to the Special Issue Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering)
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Review

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20 pages, 1071 KB  
Review
Bone Tissue Engineering: Scaffold Design Principles, Biomaterial Advances, and Strategies for Functional Regeneration and Clinical Translation
by Naznin Sultana
Bioengineering 2026, 13(5), 514; https://doi.org/10.3390/bioengineering13050514 - 29 Apr 2026
Abstract
Bone is a hierarchically organized composite material with unique mechanical properties and an intrinsic regenerative capacity that conventional repair strategies, including autografts, allografts, xenografts, and metallic or ceramic implants, fail to fully replicate due to donor scarcity, immunogenicity, mechanical mismatch, and poor long-term [...] Read more.
Bone is a hierarchically organized composite material with unique mechanical properties and an intrinsic regenerative capacity that conventional repair strategies, including autografts, allografts, xenografts, and metallic or ceramic implants, fail to fully replicate due to donor scarcity, immunogenicity, mechanical mismatch, and poor long-term integration. Bone tissue engineering (TE) offers a biologically informed alternative by integrating osteoconductive scaffolds, osteogenic progenitor cells, and osteoinductive signaling molecules into a unified regenerative framework. Unlike existing reviews that evaluate these components in isolation, this review provides a mechanistically integrated analysis that repositions scaffold design as a biologically instructive platform whose topography, stiffness, porosity, and surface chemistry collectively govern cell adhesion, mechanotransduction, osteogenic differentiation, and extracellular matrix remodeling. Critically, it moves beyond cataloging materials and fabrication approaches to evaluate how specific scaffold features drive biological outcomes and to identify frequently understated limitations, including polymer-ceramic degradation kinetics and the inadequacy of small-animal models for clinical translation. By synthesizing advances in biomaterials, additive manufacturing, and smart scaffold technologies within this integrative framework, this review provides researchers and clinicians with a structured framework for evaluating emerging strategies and prioritizing future directions in functional bone regeneration. Full article
(This article belongs to the Special Issue Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering)
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34 pages, 2842 KB  
Review
Emerging Smart and Adaptive Hydrogels for Next-Generation Tissue Engineering
by Soheil Sojdeh, Amirhosein Panjipour, Miranda Castillo, Zohreh Arabpour and Ali R. Djalilian
Bioengineering 2026, 13(1), 50; https://doi.org/10.3390/bioengineering13010050 - 31 Dec 2025
Cited by 1 | Viewed by 1614
Abstract
Tissue engineering is entering a new era, one defined not by passive scaffolds but by smart, adaptive biomaterials that can sense, think, and respond to their surroundings. These next-generation materials go beyond simply providing structure; they interact with cells and tissues in real [...] Read more.
Tissue engineering is entering a new era, one defined not by passive scaffolds but by smart, adaptive biomaterials that can sense, think, and respond to their surroundings. These next-generation materials go beyond simply providing structure; they interact with cells and tissues in real time. Recent advances in mechanically responsive hydrogels and dynamic crosslinking have demonstrated how materials can adjust their stiffness, repair themselves, and transmit mechanical cues that directly influence cell behavior and tissue growth. Meanwhile, in vivo studies are demonstrating how engineered materials can harness the body’s own mechanical forces to activate natural repair programs without relying on growth factors or additional ligands, paving the way for minimally invasive, force-based therapies. The emergence of electroactive and conductive biomaterials has further expanded these capabilities, enabling two-way electrical communication with excitable tissues such as the heart and nerves, supporting more coordinated and mature tissue growth. Meanwhile, programmable bioinks and advanced bioprinting technologies now allow for precise spatial patterning of multiple materials and living cells. These printed constructs can adapt and regenerate after implantation, combining architectural stability with flexibility to respond to biological changes. This review brings together these cross-cutting advances, dynamic chemical design, mechanobiology-guided engineering, bioelectronic integration, and precision bio-fabrication to provide a comprehensive view of the path forward in this field. We discuss key challenges, including scalability, safety compliance, and real-time sensing validation, alongside emerging opportunities such as in situ stimulation, personalized electromechanical sites, and closed loop “living” implants. Taken together, these adaptive biomaterials represent a transformative step toward information-rich, self-aware scaffolds capable of guiding regeneration in patient-specific pathways, blurring the boundary between living tissue and engineered material. Full article
(This article belongs to the Special Issue Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering)
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