Engineering Mesenchymal Stem Cells for Regenerative Medicine
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 33
Special Issue Editors
Interests: tissue engineering; regenerative medicine; mesenchymal stem cell; stem cells
Special Issue Information
Dear Colleagues,
Mesenchymal stem cells (MSCs) have emerged as a powerful tool in regenerative medicine due to their multipotency, immunomodulatory properties, and ability to secrete bioactive factors that promote tissue regeneration. This Special Issue focuses on the latest advancements in engineering MSCs to enhance their therapeutic potential, including genetic modifications, biomaterial integration, bioactive factor secretion, and improved protocols for their derivation from tissues, pluripotent stem cells, and direct reprogramming, as well as their characterization and differentiation. We aim to explore novel strategies that optimize MSC-based therapies, address challenges such as immune rejection and viability loss, and accelerate clinical translation. This Special Issue welcomes original research and comprehensive reviews on MSC-based biomaterials, mechanistic insights into MSC differentiation, engineered MSC therapies for specific diseases, advances in cell delivery and storage systems, and the role of secreted bioactive factors in tissue repair. By bringing together cutting-edge research, this Special Issue will provide a comprehensive outlook on the future of MSC engineering in regenerative medicine.
Dr. Kyungsook Kim
Dr. Luis G. Villa-Diaz
Guest Editors
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Keywords
- mesenchymal stem cell (MSC) engineering
- genetic modification of MSCs
- MSC biomaterial integration
- surface modification of MSCs
- MSC sheet engineering
- scaffold-free MSC delivery
- MSC bioactive factor secretion
- direct MSC reprogramming
- engineered MSC characterization and differentiation
- improved protocols for MSC derivation from tissues and pluripotent
- clinical translation strategy of engineered MSCs
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