Innovative Biomaterials and Advanced Technologies in Bone Tissue Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 1 November 2025 | Viewed by 699

Special Issue Editor

Special Issue Information

Dear Colleagues,

The use of biomaterials in dentistry, maxillofacial surgery, and orthopedics is increasingly important for advancing healthcare. Bone repair and regeneration continue to pose significant clinical challenges, with a growing global demand for more effective solutions. Despite the widespread use of traditional grafting methods, there are limitations related to the availability and quality of transplants. Therefore, there is a growing demand for innovative alternatives, such as natural and synthetic biomaterials, which can act as scaffolds for hard tissue regeneration. Additionally, advancements in implants, prosthetics, and digital dentistry are reshaping functional and aesthetic rehabilitation approaches for patients.

This Special Issue will cover the latest developments in biomaterials, with a focus on their properties, mechanical behaviors, and interactions with cells and tissues. It will also explore their role in osseointegration and the long-term sustainability of implants and prosthetics. State-of-the-art tissue engineering strategies, including the integration of biomaterials with various cell types, growth factors, and extracellular vesicles, will be highlighted to enhance bone tissue regeneration. Moreover, the role of digital tools, including numerical studies and computational simulations, will be emphasized for its contributions to improving implant design and prosthetic performance.

The aim of this Special Issue is to enhance the efficacy, longevity, and precision of medical implants, prosthetics, and bone substitute materials, ultimately improving patient outcomes and quality of life. Original research articles, comprehensive reviews, short communications, and mini-reviews reporting on innovative biomaterials, tissue engineering strategies, implant surface technologies, prosthetic innovations, numerical modeling, and digital workflows are encouraged.

In summary, this collection will explore the development of cutting-edge biomaterials and techniques for improving implant performance, bone regeneration, and prosthetics in dental and orthopedic fields. It aims to promote interdisciplinary collaboration and push the boundaries of current practices, ultimately advancing healthcare solutions for patients worldwide.

Tea Romasco
Guest Editor Assistant
Affiliation: Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy

Dr. Natalia Di Pietro
Guest Editor

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Keywords

  • biomaterials
  • bone tissue regeneration
  • tissue engineering
  • scaffolds
  • prosthetics
  • dental implants
  • osseointegration
  • numerical studies
  • biomechanics
  • digital dentistry

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Published Papers (1 paper)

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Research

13 pages, 1243 KiB  
Article
Three-Dimensional Assessment of the Biological Periacetabular Defect Reconstruction in an Ovine Animal Model: A µ-CT Analysis
by Frank Sebastian Fröschen, Thomas Martin Randau, El-Mustapha Haddouti, Jacques Dominik Müller-Broich, Frank Alexander Schildberg, Werner Götz, Dominik John, Susanne Reimann, Dieter Christian Wirtz and Sascha Gravius
Bioengineering 2025, 12(7), 729; https://doi.org/10.3390/bioengineering12070729 - 3 Jul 2025
Viewed by 350
Abstract
The increasing number of acetabular revision total hip arthroplasties requires the evaluation of alternative materials in addition to established standards using a defined animal experimental defect that replicates the human acetabular revision situation as closely as possible. Defined bone defects in the load-bearing [...] Read more.
The increasing number of acetabular revision total hip arthroplasties requires the evaluation of alternative materials in addition to established standards using a defined animal experimental defect that replicates the human acetabular revision situation as closely as possible. Defined bone defects in the load-bearing area of the acetabulum were augmented with various materials in an ovine periacetabular defect model (Group 1: NanoBone® (artificial hydroxyapatite-silicate composite; Artoss GmbH, Germany); Group 2: autologous sheep cancellous bone; Group 3: Tutoplast® (processed allogeneic sheep cancellous bone; Tutogen Medical GmbH, Germany)) and bridged with an acetabular reinforcement ring of the Ganz type. Eight months after implantation, a μ-CT examination (n = 8 animals per group) was performed. A μ-CT analysis of the contralateral acetabula (n = 8, randomly selected from all three groups) served as the control group. In a defined volume of interest (VOI), bone volume (BV), mineral volume (MV), and bone substitute volume (BSV), as well as the bone surface (BS) relative to the total volume (TV) and the surface-to-volume ratio (BS/BV), were determined. To assess the bony microarchitecture, trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N), as well as connectivity density (Conn.D), the degree of anisotropy (DA), and the structure model index (SMI), were evaluated. The highest BV was observed for NanoBone® (Group 1), which also showed the highest proportion of residual bone substitute material in the defect. This resulted in a significant increase in BV/TV with a significant decrease in BS/BV. The assessment of the microstructure for Groups 2 and 3 compared to Group 1 showed a clear approximation of Tb.Th, Tb.Sp, Tb.N, and Conn.D to the microstructure of the control group. The SMI showed a significant decrease in Group 1. All materials demonstrated their suitability by supporting biological defect reconstruction. NanoBone® showed the highest rate of new bone formation; however, the microarchitecture indicated more advanced bone remodeling and an approximate restoration of the trabecular structure for both autologous and allogeneic Tutoplast® cancellous bone when using the impaction bone grafting technique. Full article
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