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Applied Sciences
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Advances in Translational Nanotechnology
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Advances in Translational Nanotechnology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 24524

Special Issue Editors

Prof. Dr. Shyam (Sam) S. Mohapatra<br/>2019 NanoFlorida International Conference Chair

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Guest Editor
Center for Research and Education in NanoBioengineering, Department of Internal Medicine, Morsani College of Medicine; and USF College of Pharmacy Graduate Programs, College of Pharmacy: University of South Florida; 4202, E Fowler Ave, ENG30, Tampa, FL 33620, USA
Interests: biomedical nanotechnology; nano-enabled diagnostics and prognostics; nanotherapeutics; biomedical engineering; precision medicine; precision oncology; acoustic biosensing
Prof. Dr. Manh-Huong Phan

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Co-Guest Editor
Department of Physics, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
Interests: nanomaterials; nanomagnetism; nanospintronics; nanobiosensors; biomedical applications of functional magnetic nanoparticles
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Robert Frisina<br/>2019 NanoFlorida International Conference Co-Chair

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Co-Guest Editor
Department ofMedical Engineering, College of Engineering, 4202, E Fowler Ave, ENG30, Tampa, FL 33620, USA
Interests: biomedical engineering systems for drug delivery systems for the ear
Dr. Subhra Mohapatra<br/>2019 NanoFlorida International Conference Co-Chair

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Co-Guest Editor
Department of Molecular Medicine, University of South Florida, 4202, E Fowler Ave, ENG30, Tampa, FL 33620, USA
Interests: nanotherapeutics for traumatic brain injury and cancers; nanoscale drug delivery; precision oncology
Prof. Dr. Mandip S. Sachdeva

E-Mail Website
Co-Guest Editor
Department of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA
Interests: pharmaceutical; nanotherapeutics; nanoscale drug delivery; 3D printing

Special Issue Information

Dear Colleagues,

In the last two decades, the science of nanotechnology that deals with materials in nanoscale (from 1 to 100 nm), which significantly changes the electrical, magnetic, and optical properties of matter, has been a dynamic revolutionary force that is exponentially impacting societies around the world. Nanoscience and nanotechnology aim to create, understand, and use nanoscale structures, devices, and systems having novel properties and functionalities. Through ground-breaking scientific and technological advancements, nanotechnology-based products are becoming fully integrated into our daily lives. The nanotechnology revolution embodies an interdisciplinary approach and is bringing scientists together from nearly every area of scientific study. A worldwide collaboration is significantly enhancing the quality of construction materials, machinery, automobiles, electronics, renewable energy, transportation, common appliances, consumer products, entertainment, agriculture, microscopy, scientific instrumentation, healthcare, diagnostic assays, and nano-enabled drug discovery and development. This Special Issue of Applied Sciences will be devoted to bringing together the latest advances in various fields of applied nanoscience and nanotechnology in one compendium. The articles submitted in response to this Special Issue may comprise reviews of advances in a field, research articles and 1–2 page research reports.

This Special Issue coincides with the 2019 NanoFlorida International Conference, to be held on November 15–17, 2019, which provides world-leading scientists with a venue to present the latest research in the field and discuss new directions and collaborations. Topics for NanoFlorida symposia evolve with developments in the fields of nanoscience and engineering, and the 2019 NanoFlorida International Conference will focus on the theme of “Advances in Translational Nanobiotechnology”. Parallel symposia will be organized to address scientific advances in nanobiotechnology, biosensing, microfluidics, nanodiagnostics and nanoimaging, gene and cell technology, bioprinting, nanoscale drug delivery, and other cutting-edge areas of research, which can be part of this Special Issue.

Prof. Shyam (Sam) S. Mohapatra
Prof. Manh-Huong Phan
Prof. Robert Frisina
Prof. Subhra Mohapatra
Prof. Mandip Singh Sachdeva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoelectronics
  • Nanodiagnostics and imaging
  • Nanomaterials and devices
  • Nanoscale drug delivery
  • Bioprinting
  • Microfluidics
  • Tissue engineering
  • Nanopharmaceutics
  • Nano-biotechnology
  • Gene and cell technology
  • Sustainable environment
  • Agriculture and food safety

Published Papers (7 papers)

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Research

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13 pages, 4102 KiB  
Communication
In Situ Assembly of Gold Nanoparticles in the Presence of Poly-DADMAC Resulting in Hierarchical and Highly Fractal Nanostructures
by J. Michael Köhler and Jonas Kluitmann
Appl. Sci. 2021, 11(3), 1191; https://doi.org/10.3390/app11031191 - 28 Jan 2021
Cited by 2 | Viewed by 1978
Abstract
The presence of the polycationic macromolecule poly(diallyldimethylammonium chloride) (poly-DADMAC) has a strong effect on the shape and size of colloidal gold nanoparticles formed by the reduction of tetrachloroauric acid with ascorbic acid in aqueous solution. It slows down nanoparticle growth and supports the [...] Read more.
The presence of the polycationic macromolecule poly(diallyldimethylammonium chloride) (poly-DADMAC) has a strong effect on the shape and size of colloidal gold nanoparticles formed by the reduction of tetrachloroauric acid with ascorbic acid in aqueous solution. It slows down nanoparticle growth and supports the formation of nonspherical, partially highly fractal and hierarchical nanoparticle shapes. Four structural levels have been recognized from the near-spherical gold nanoparticles in the lower nanometer range over compact aggregates in the midnanometer range and flower and star-like particles in the submicron range up to larger filamentous aggregates. High-contrast scanning electron microscope (SEM) images show that single gold nanoparticles and clusters of them are connected by bundles of macromolecules in large aggregates. The investigation showed that a large spectrum of different nanoparticle shapes and sizes can be accessed by tuning the poly-DADMAC concentrations and their ratio to other reactants. The nanoassemblies with a very high specific surface area might be of interest for SERS and heterogeneous catalysis. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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10 pages, 3420 KiB  
Article
Role of Magnetic Anisotropy on the Hyperthermia Efficiency in Spherical Fe3−xCoxO4 (x = 0–1) Nanoparticles
by Raja Das, Ngoc Pham Kim, Supun B. Attanayake, Manh-Huong Phan and Hariharan Srikanth
Appl. Sci. 2021, 11(3), 930; https://doi.org/10.3390/app11030930 - 20 Jan 2021
Cited by 19 | Viewed by 2566
Abstract
The use of magnetic nanoparticles in the treatment of cancer using alternating current hyperthermia therapy has shown the potential to replace or supplement conventional cancer treatments, radiotherapy and chemotherapy, which have severe side effects. Though the nearly spherical sub-10 nm iron oxide nanoparticles [...] Read more.
The use of magnetic nanoparticles in the treatment of cancer using alternating current hyperthermia therapy has shown the potential to replace or supplement conventional cancer treatments, radiotherapy and chemotherapy, which have severe side effects. Though the nearly spherical sub-10 nm iron oxide nanoparticles have their approval from the US Food and Drug Administration, their low heating efficiency and removal from the body after hyperthermia treatment raises serious concerns. The majority of magnetic hyperthermia research is working to create nanomaterials with improved heating efficiency and long blood circulation time. Here, we have demonstrated a simple strategy to enhance the heating efficiency of sub-10 nm Fe3O4 nanoparticles through the replacement of Fe+2 ions with Co+2 ions. Magnetic and hyperthermia experiments on the 7 nm Fe3−xCoxO4 (x = 0–1) nanoparticles showed that the blocking temperature, the coercivity at 10 K, and the specific absorption rate followed a similar trend with a maximum at x = 0.75, which is in corroboration with the theoretical prediction. Our study revealed that the heating efficiency of the Fe3−xCoxO4 (x = 0–1) nanoparticles varies not just with the size and saturation magnetization but also with the magnetocrystalline anisotropy of the particles. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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Review

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18 pages, 1505 KiB  
Review
Advances in Translational Nanotechnology: Challenges and Opportunities
by Shyam S. Mohapatra, Robert D. Frisina, Subhra Mohapatra, Kevin B. Sneed, Eleni Markoutsa, Tao Wang, Rinku Dutta, Ratka Damnjanovic, Manh-Huong Phan, Daniel J. Denmark, Manas R. Biswal, Andrew R. McGill, Ryan Green, Mark Howell, Payal Ghosh, Alejandro Gonzalez, Nadia Tasnim Ahmed, Brittney Borresen, Mitchell Farmer, Melissa Gaeta, Krishna Sharma, Christen Bouchard, Danielle Gamboni, Jamie Martin, Bianca Tolve, Mandip Singh, Jack W. Judy, Chenzhong Li, Swadeshmukul Santra, Sylvia Daunert, Elnaz Zeynaloo, Ryan M. Gelfand, Steven Lenhert, Eric S. McLamore, Dong Xiang, Victoria Morgan, Lisa E. Friedersdorf, Ratnesh Lal, Thomas J. Webster, David P. Hoogerheide, Thanh Duc Nguyen, Martin J. D'Souza, Mustafa Çulha, Pierre P. D. Kondiah and Donald K. Martinadd Show full author list remove Hide full author list
Appl. Sci. 2020, 10(14), 4881; https://doi.org/10.3390/app10144881 - 16 Jul 2020
Cited by 4 | Viewed by 4820
Abstract
The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area [...] Read more.
The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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28 pages, 4407 KiB  
Review
Quantum Leap from Gold and Silver to Aluminum Nanoplasmonics for Enhanced Biomedical Applications
by Sharad Ambardar, Dang Nguyen, Grace Binder, Zachary W. Withers and Dmitri V. Voronine
Appl. Sci. 2020, 10(12), 4210; https://doi.org/10.3390/app10124210 - 19 Jun 2020
Cited by 14 | Viewed by 5623
Abstract
Nanotechnology has been used in many biosensing and medical applications, in the form of noble metal (gold and silver) nanoparticles and nanostructured substrates. However, the translational clinical and industrial applications still need improvements of the efficiency, selectivity, cost, toxicity, reproducibility, and morphological control [...] Read more.
Nanotechnology has been used in many biosensing and medical applications, in the form of noble metal (gold and silver) nanoparticles and nanostructured substrates. However, the translational clinical and industrial applications still need improvements of the efficiency, selectivity, cost, toxicity, reproducibility, and morphological control at the nanoscale level. In this review, we highlight the recent progress that has been made in the replacement of expensive gold and silver metals with the less expensive aluminum. In addition to low cost, other advantages of the aluminum plasmonic nanostructures include a broad spectral range from deep UV to near IR, providing additional signal enhancement and treatment mechanisms. New synergistic treatments of bacterial infections, cancer, and coronaviruses are envisioned. Coupling with gain media and quantum optical effects improve the performance of the aluminum nanostructures beyond gold and silver. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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17 pages, 1313 KiB  
Review
Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications
by Riddhi Vichare, Inyoung Garner, Ryan J. Paulson, Radouil Tzekov, Nurettin Sahiner, Siva K. Panguluri, Subhra Mohapatra, Shyam S. Mohapatra, Ramesh Ayyala, Kevin B. Sneed and Manas R. Biswal
Appl. Sci. 2020, 10(12), 4189; https://doi.org/10.3390/app10124189 - 18 Jun 2020
Cited by 12 | Viewed by 3018
Abstract
Drug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during the process. Significant [...] Read more.
Drug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during the process. Significant research using chitosan, a cationic linear polymer, is being conducted for ocular drug delivery. A vast number of publications exploit the mucoadhesive properties of the polymer, which arise due to interactions between the amino acids of chitosan and the sialic acid residues in mucous. The high degree of crosslinking in chitosan nanoparticles facilitates a dramatic increase in ocular drug retention of the desired drug, which subsequently helps in ocular penetration and improving the bioavailability of the drugs. A noted decrease in the initial burst of the drug is the basis for developing sustained drug release formulation using biodegradable and biocompatible chitosan polymer. In vitro as well as in vivo studies have indicated enhancement in the uptake, accumulation, and removal of chitosan nanoparticles from the site of delivery. In summary, chitosan- or modified-chitosan-based nanoparticles are being widely tested as drug carriers for treatment of bacterial and viral infections, glaucoma, age-related macular degeneration, and diabetic retinopathy. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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8 pages, 921 KiB  
Review
Challenges for the Implantation of Symbiotic Nanostructured Medical Devices
by Jean-Pierre Alcaraz, Gauthier Menassol, Géraldine Penven, Jacques Thélu, Sarra El Ichi, Abdelkader Zebda, Philippe Cinquin and Donald K. Martin
Appl. Sci. 2020, 10(8), 2923; https://doi.org/10.3390/app10082923 - 23 Apr 2020
Cited by 4 | Viewed by 2340
Abstract
We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends [...] Read more.
We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends the existing concepts of a biomaterial and biocompatibility to include the notion that it is important to consider the intended functional use of the implanted medical device. This demands a biomimetic approach to design functional symbiotic implantable medical devices that can be more efficient in mimicking what is happening at the molecular and cellular levels to create stable interfaces that allow for the unfettered exchanges of molecules between an implanted device and a body. Such a duplex level of communication is considered to be a necessary characteristic of symbiotic implanted medical devices that are designed to function for long periods of time inside the body to restore and assist the function of the body. We illustrate these perspectives with experience gained from implanting functional enzymatic biofuel cells. Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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Other

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94 pages, 11001 KiB  
Meeting Report
Proceedings of the 2019 NanoFlorida International Conference Held at the University of South Florida, Tampa, FL
by Shyam S. Mohapatra, Robert D. Frisina, Subhra Mohapatra, Mandip Singh and Manh-Huong Phan
Appl. Sci. 2020, 10(14), 4851; https://doi.org/10.3390/app10144851 - 15 Jul 2020
Viewed by 3550
Abstract
The nanotechnology revolution embodies an interdisciplinary approach and is bringing scientists together from nearly every area of scientific study [...] Full article
(This article belongs to the Special Issue Advances in Translational Nanotechnology)
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