Synthesis of Novel Heterocyclic Compounds and Evaluation of Their Antimicrobial Activity

Dear Colleagues,

Every year, a few new drugs are introduced to the market, both so-called small-molecular chemical compounds and biological drugs. According to regularly reported data, including by the FDA, small-molecular compounds have for many years the newest pharmaceutical products most commonly approved for therapeutic use. In 2019, 38 new chemical entities were introduced for medicinal use in the USA, almost all of them heterocyclic compounds, of which about 2/3 were nitrogen heterocycles. A similar tendency has been observed in many other countries. The above facts indicate the huge potential of applications of heterocyclic compounds of various origins—both synthetic and natural—as medicinal substances.

Heterocyclic individuals are expected to be good candidates for antimicrobial agents against infectious diseases caused by all classes of microbes, which constitute a significant percentage of all diseases affecting humanity. Potential epidemics are difficult to control, often with tragic consequences.

Therefore, the use of heterocyclic compounds, both those of completely new structures and so-called repositioned entities, to combat microbial infections of various types seems to be one of the key research directions of new small-molecule chemical drugs.

This Special Issue is dedicated to presentation of results of latest research on different kinds of heterocyclic compounds, their modern and rational synthesis, general progress, and trends in heterocyclic chemistry. We would like to kindly invite researchers from all over the world to submit their original results or reviews featuring recent developments in the area of heterocyclic derivatives use to fight malicious pathogenic microbes.

Prof. Dr. Lucjusz Zaprutko
Dr. Anna Pawelczyk
Guest Editors

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