Biomedical Applications of Recombinant Glycoproteins
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 5673
Special Issue Editor
Interests: thrombosis; hemophilia; drug discovery and design
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recombinant proteins are the products of exogenous DNA translation in living expression systems. Recombinant proteins represent a powerful platform that is extensively exploited in biomedical sciences with significant applications in research, biotechnology, and disease treatment, prevention, and diagnosis. Recombinant proteins are frequently used in molecular and cell biology as well as in structural, biochemical, and biophysical studies. Recombinant proteins are useful tools for studying protein–protein interactions and for performing Western Blot, ELISA, immunohistochemistry, and enzyme assays. They also have meaningful use in food industry, agriculture, and bioengineering. Importantly, recombinant proteins have emerged as life-changing therapies. They include recombinant hormones, interleukins, interferons, tumor necrosis factors, growth factors, thrombolytic drugs, blood clotting factors, monoclonal antibodies, vaccines, and enzymes. Thus, many disease conditions benefit from the use of therapeutic recombinant proteins. Interestingly, most of the approved therapeutic proteins in the EU and US markets are recombinant glycoproteins which are recombinant proteins modified by post-translational glycosylation. Glycosylation is highly dependent on the expression system and may eventually dictate the use of the resulting recombinant proteins.
With the advancement of modern technology, the biomedical applications of recombinant proteins in general, and recombinant glycoproteins in particular, will continue to expand. Therefore, in this Special Issue on "Biomedical Applications of Recombinant Glycoproteins", we invite principal investigators who are interested in recombinant glycoproteins to contribute original research articles as well as review articles so to advance our fundamental and technical knowledge relevant to recombinant glycoproteins, with a particular emphasis on their biomedical applications.
Dr. Rami A. Al-Horani
Guest Editor
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Keywords
- Recombinant glycoproteins
- Therapeutic glycoproteins
- Recombinant hormones
- Recombinant monoclonal antibodies
- Vaccines
- Glycosylation
- Expression system
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