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Volume 10
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10.3390/app10124109
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Article

Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

by
Małgorzata Seredyka-Burduk
1,†,
Michał Wiciński
2,†,
Sławomir Liberski
2,*,
Daria Marczak
2,
Magdalena Pol
1,
Bartosz Malinowski
2 and
Bartlomiej J. Kaluzny
1
1
Division of Ophthalmology and Optometry, Department of Ophthalmology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
2
Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally to this work.
Appl. Sci. 2020, 10(12), 4109; https://doi.org/10.3390/app10124109
Submission received: 5 May 2020 / Revised: 6 June 2020 / Accepted: 11 June 2020 / Published: 15 June 2020
(This article belongs to the Special Issue Biomedical Applications of Recombinant Glycoproteins)
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Abstract

We evaluated the effect of three monthly intravitreal injections of aflibercept on the serum concentration of interleukin 17A (IL-17A), monocyte chemoattractant protein 1 (MCP-1/CCL2), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in treatment-naive patients with neovascular age-related macular degeneration (nAMD). Twenty-two eyes of twenty-two patients with nAMD scheduled for the initial loading phase of intravitreal aflibercept (2 mg/0.05 mL) were included. Serum VEGF, PlGF, MCP-1/CCL2 and IL-17A levels were determined four times in each individual—just before the first injection, 2–3 days after the first injection, just before the third injection, and then 2–3 days after the third aflibercept injection. A statistically significant difference was found between the serum PlGF and IL-17A levels measured before the first injection and after the initial loading phase, with a mean value (MV) of 440.884 vs. 302.151 (p = 0.023) for PlGF and MV = 139.088 pg/mL vs. 151.233 pg/mL (p = 0.016) for IL-17A, respectively. There were no statistically significant differences for VEGF and MCP-1/CCL2 between any of the compared measurements. We reveal that repeated injections of aflibercept promote an increase in serum IL-17A concentration, which may lead to a systemic inflammatory response mediated by IL-17A, but not by MCP-1.
Keywords: aflibercept; interleukin-17; IL-17; monocyte chemoattractant protein 1; MCP-1/CCL2; vascular endothelial growth factor; VEGF; placental growth factor; PlGF; age-related macular degeneration; AMD aflibercept; interleukin-17; IL-17; monocyte chemoattractant protein 1; MCP-1/CCL2; vascular endothelial growth factor; VEGF; placental growth factor; PlGF; age-related macular degeneration; AMD

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MDPI and ACS Style

Seredyka-Burduk, M.; Wiciński, M.; Liberski, S.; Marczak, D.; Pol, M.; Malinowski, B.; Kaluzny, B.J. Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration. Appl. Sci. 2020, 10, 4109. https://doi.org/10.3390/app10124109

AMA Style

Seredyka-Burduk M, Wiciński M, Liberski S, Marczak D, Pol M, Malinowski B, Kaluzny BJ. Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration. Applied Sciences. 2020; 10(12):4109. https://doi.org/10.3390/app10124109

Chicago/Turabian Style

Seredyka-Burduk, Małgorzata, Michał Wiciński, Sławomir Liberski, Daria Marczak, Magdalena Pol, Bartosz Malinowski, and Bartlomiej J. Kaluzny. 2020. "Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration" Applied Sciences 10, no. 12: 4109. https://doi.org/10.3390/app10124109

APA Style

Seredyka-Burduk, M., Wiciński, M., Liberski, S., Marczak, D., Pol, M., Malinowski, B., & Kaluzny, B. J. (2020). Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration. Applied Sciences, 10(12), 4109. https://doi.org/10.3390/app10124109

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