Innovative Therapeutics towards Personalized Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 1480

Special Issue Editor

Special Issue Information

Dear Colleagues,

With the promise of delivering the right treatment at the right time to the right person, personalized medicine stands at the edge of the innovation revolution in healthcare.

As such, we are currently witnessing a paradigm transformation in healthcare since cutting-edge technologies are rapidly invading and leading the diagnostics and treatments provided to patients worldwide. Technological advances in the fields of engineering, robotics, nano- and micro-technologies, genomics and other ‘omics’, artificial intelligence, and big data are amongst the most relevant scientific breakthroughs improving our knowledge of disease diagnostics and treatment. In that manner, we can provide more precise, predictive, and personalized health care fitted to each individual patient, improving quality of life and reducing healthcare costs.

A major challenge faced by personalized medicine is the development of newer, safer, and custom-made therapeutic forms that do not increase costs and reduce the life cycle for the development of new therapeutic approaches. Patient access to new drugs, devices, and treatments is perhaps the biggest challenge to be solved by personalized medicine in the future.

In this way, research into innovative therapies aims to assist patient access to new forms of therapy through the development of new, economically sustainable, safe, and accessible technologies to improve outcomes for patients and the population.

The goal of this Special Issue is to promote discussions on innovative therapies as alternatives to old problems, such as antibiotic resistance and the treatment of orphan diseases; emerging approaches such as telemedicine and telesurgery; and the use of cutting-edge technologies such as nanofabrication, drug design, and intelligent drug delivery, among others.

Prof. Dr. Rúben Fernandes
Guest Editor

Manuscript Submission Information

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Keywords

  • innovative medicine
  • gene therapy
  • cell therapy
  • immune therapy
  • endocrine therapy
  • phage therapy
  • photodynamic therapy
  • hyperbaric oxygen therapy
  • biotherapy
  • medical devices
  • nanomedicines
  • computational drug design

Published Papers (1 paper)

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Research

13 pages, 1960 KiB  
Article
The Magic Cocktail: Ampicillin and Biosynthesized Gold Nanoparticles Synergism against Staphylococcus aureus
by Marco Oliveira, Silvia Soares, Sara Sá, Álvaro Gestoso, Miguel Correa-Duarte, Pilar Baylina, Rúben Fernandes and Carla F. Pereira
Appl. Sci. 2023, 13(19), 10934; https://doi.org/10.3390/app131910934 - 03 Oct 2023
Viewed by 958
Abstract
Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C [...] Read more.
Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirmed through UV-Vis spectroscopy, exhibiting a characteristic peak within the 500–600 nm wavelength range, and the evaluation of the main functional groups and morphology were stressed by Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM), respectively. Subsequently, the synthesized bAuNPs were combined with low concentrations of ampicillin and evaluated against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) through the classical serial dilution method. This innovative approach holds the potential to address the escalating issue of antibiotic resistance, providing a viable and sustainable solution. Full article
(This article belongs to the Special Issue Innovative Therapeutics towards Personalized Medicine)
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